@article{7ed4e33895104763b818aa76d1bca68d,
title = "KIF15 Εxpression in Τumor-associated Μonocytes Ιs a prognostic biomarker in hepatocellular carcinoma",
abstract = "Background/Aim: Kinesin family member 15 (KIF15) participates in the transport of macromolecules in essential cellular processes. In this study we evaluated the clinical relevance of KIF15 expression in hepatocellular carcinoma (HCC). Materials and Methods: Association between KIF15 expression and clinical outcomes in HCC patients was analyzed using three independent cohorts. Localization of KIF15 expression was assessed by immunohistochemical analysis. Co-culture experiments were performed using healthy donor peripheral blood mononuclear cells (PBMC) and HCC cell lines. Results: Immunohistochemical analysis showed that KIF15 was mainly expressed in inflammatory monocytes around cancer cells. Multivariate analysis indicated high KIF15 expression was an independent poor prognostic factor for survival. HCC cells with high expression of minichromosome maintenance protein 2 (MCM2) were located close to KIF15-expressing inflammatory monocytes. The proliferation ability of HCC cells was increased by co-culture with PBMC. Conclusion: High KIF15 expression in inflammatory monocytes in tumor tissues may serve as a prognostic marker for poor outcome in HCC.",
author = "Akihiro Kitagawa and Takaaki Masuda and Junichi Takahashi and Taro Tobo and Miwa Noda and Yohsuke Kuroda and Qingjiang Hu and Yuta Kouyama and Yuta Kobayashi and Shotaro Kuramitsu and Kuniaki Sato and Atsushi Fujii and Yukihiro Yoshikawa and Hiroaki Wakiyama and Dai Shimizu and Yusuke Tsuruda and Hidetoshi Eguchi and Yuichiro Doki and Masaki Mori and Koshi Mimori",
note = "Funding Information: The Authors would like to thank K. Oda, M. Kasagi, S. Sakuma, N. Mishima, T. Kawano, M. Oshiumi and M. Utou for their technical assistance. This work was supported in part by the following Grants and foundations: Japan Society for the Promotion of Science Grant-in-Aid for Science R esearch (Grant Numbers JP16K07177, JP16K10543, JP17K16454, JP17K16521, JP17K10593 and JP17K19608); OITA Cancer R esearch Foundation; Daiwa Securities Health Foundation; Grant-in-Aid for Scientific R esearch on Innovative Areas (15H0912); Priority Issue on Post-K computer (hp170227) (hp170227, hp160219); JSPS KAKENHI (15H05707); Japanese Foundation for Multidisciplinary Treatment of Cancer. HCC clinical samples were provided by the Oita R ed Cross Hospital, Hiroshima R ed Cross Hospital, Atomic-bomb Survivors Hospital, and Iizuka Hospital. Funding Information: The Authors would like to thank K. Oda, M. Kasagi, S. Sakuma, N. Mishima, T. Kawano, M. Oshiumi and M. Utou for their technical assistance. This work was supported in part by the following Grants and foundations: Japan Society for the Promotion of Science Grant-in-Aid for Science Research (Grant Numbers JP16K07177, JP16K10543, JP17K16454, JP17K16521, JP17K10593 and JP17K19608); OITA Cancer Research Foundation; Daiwa Securities Health Foundation; Grant-in-Aid for Scientific Research on Innovative Areas (15H0912); Priority Issue on Post-K computer (hp170227) (hp170227, hp160219); JSPS KAKENHI (15H05707); Japanese Foundation for Multidisciplinary Treatment of Cancer. HCC clinical samples were provided by the Oita Red Cross Hospital, Hiroshima Red Cross Hospital, Atomic-bomb Survivors Hospital, and Iizuka Hospital. Publisher Copyright: {\textcopyright} 2020 International Institute of Anticancer Research. All rights reserved.",
year = "2020",
doi = "10.21873/cgp.20174",
language = "English",
volume = "17",
pages = "141--149",
journal = "Cancer Genomics and Proteomics",
issn = "1109-6535",
publisher = "International Institute of Anticancer Research",
number = "2",
}
