TY - JOUR
T1 - Kidney transplantation for treatment of end-stage kidney disease after haematopoietic stem cell transplantation
T2 - case series and literature review
AU - the Japan Academic Consortium of Kidney Transplantation (JACK) Investigators
AU - Tsuchimoto, Akihiro
AU - Masutani, Kosuke
AU - Omoto, Kazuya
AU - Okumi, Masayoshi
AU - Okabe, Yasuhiro
AU - Nishiki, Takehiro
AU - Ota, Morihito
AU - Nakano, Toshiaki
AU - Tsuruya, Kazuhiko
AU - Kitazono, Takanari
AU - Nakamura, Masafumi
AU - Ishida, Hideki
AU - Tanabe, Kazunari
AU - Tanabe, Kazunari
AU - Inui, Masashi
AU - Shimizu, Tomokazu
AU - Hirai, Toshihito
AU - Toki, Daisuke
AU - Unagami, Kohei
AU - Toma, Hiroshi
AU - Shirakawa, Hiroki
AU - Doi, Atsuchi
AU - Kaku, Keizo
AU - Kurihara, Kei
AU - Morihito, Ota
N1 - Funding Information:
Conflict of interest Potential financial conflicts of interest: Astellas Pharma Inc. (Tokyo, Japan) supported this study and Kazunari Tanabe with a grant. The sponsor was not involved in the study design, patient enrolment, data collection, analysis, interpretation, or preparation of the manuscript.
Funding Information:
We thank Dr Nicholas Rufaut, PhD, and Mitchell Arico from Edanz Group (http://www.edanzediting.com/ac) for editing a draft of this manuscript. We appreciate the support from Katsunori Shimada, PhD (STATZ Institute, Inc., Tokyo, Japan), who provided expert assistance with data management. JACK Participating Centres: Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan; Investigators, Kazunari Tanabe, Hideki Ishida, Masashi Inui, Kazuya Omoto, Tomokazu Shimizu, Masayoshi Okumi, Toshihito Hirai, and Daisuke Toki; Department of Medicine, Kidney Centre, Tokyo Women’s Medical University, Tokyo, Japan; Investigator, Kohei Unagami; Department of Transplant Surgery, Kidney Centre, Toda Chuo General Hospital; Investigator, Hiroshi Toma; Department of Urology, Ohkubo Hospital; Investigator, Hiroki Shirakawa; Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan; Investigators, Yasuhiro Okabe, Atsuchi Doi, Keizo Kaku, and Kei Kurihara; Department of Surgery, Tomishiro Central Hospital, Okinawa; Investigator, Ota Morihito. JACK Data Centre: Katsunori Shimada, Department of Biostatistics, STATZ Institute, Inc., Tokyo, Japan. JACK General Management Office: Masayoshi Okumi, Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan.
Publisher Copyright:
© 2018, Japanese Society of Nephrology.
PY - 2019/4/2
Y1 - 2019/4/2
N2 - Background: The safety of kidney transplantation (KT) for end-stage kidney disease (ESKD) after haematopoietic stem cell transplantation (HSCT) for haematological disease has not been investigated thoroughly. Methods: In this retrospective multicentre study, we investigated the clinical courses of six ESKD patients that received KT after HSCT for various haematological diseases. Data for six such patients were obtained from three institutions in our consortium. Results: Two patients with chronic myeloid leukaemia, one with refractory aplastic anaemia and another one with acute lymphocytic leukaemia received bone marrow transplantation. One patients with acute lymphocytic leukaemia received umbilical cord blood transplantation, and one with mantle cell lymphoma received peripheral blood stem cell transplantation. The patients developed ESKD at a median of 133 months after HSCT. Two patients who received KT and HSCT from the same donor were temporarily treated with immunosuppressive drugs. The other patients received KT and HSCT from different donors and were treated with antibody induction using our standard regimens. For one patient with ABO-incompatible transplantation, we added rituximab, splenectomy, and plasmapheresis. In the observational period at a median of 51 months after KT, only one patient experienced acute T-cell-mediated rejection. Four patients underwent hospitalization because of infection and fully recovered. No patient experienced recurrence of their original haematological disease. All patients survived throughout the observational periods, and graft functions were preserved. Conclusions: Despite the high infection frequency, survival rates and graft functions were extremely good in patients compared with previous studies. Therefore, current management contributed to favourable outcomes of these patients.
AB - Background: The safety of kidney transplantation (KT) for end-stage kidney disease (ESKD) after haematopoietic stem cell transplantation (HSCT) for haematological disease has not been investigated thoroughly. Methods: In this retrospective multicentre study, we investigated the clinical courses of six ESKD patients that received KT after HSCT for various haematological diseases. Data for six such patients were obtained from three institutions in our consortium. Results: Two patients with chronic myeloid leukaemia, one with refractory aplastic anaemia and another one with acute lymphocytic leukaemia received bone marrow transplantation. One patients with acute lymphocytic leukaemia received umbilical cord blood transplantation, and one with mantle cell lymphoma received peripheral blood stem cell transplantation. The patients developed ESKD at a median of 133 months after HSCT. Two patients who received KT and HSCT from the same donor were temporarily treated with immunosuppressive drugs. The other patients received KT and HSCT from different donors and were treated with antibody induction using our standard regimens. For one patient with ABO-incompatible transplantation, we added rituximab, splenectomy, and plasmapheresis. In the observational period at a median of 51 months after KT, only one patient experienced acute T-cell-mediated rejection. Four patients underwent hospitalization because of infection and fully recovered. No patient experienced recurrence of their original haematological disease. All patients survived throughout the observational periods, and graft functions were preserved. Conclusions: Despite the high infection frequency, survival rates and graft functions were extremely good in patients compared with previous studies. Therefore, current management contributed to favourable outcomes of these patients.
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U2 - 10.1007/s10157-018-1672-1
DO - 10.1007/s10157-018-1672-1
M3 - Article
C2 - 30584654
AN - SCOPUS:85059012564
SN - 1342-1751
VL - 23
SP - 561
EP - 568
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 4
ER -