TY - JOUR
T1 - KEGG for linking genomes to life and the environment
AU - Kanehisa, Minoru
AU - Araki, Michihiro
AU - Goto, Susumu
AU - Hattori, Masahiro
AU - Hirakawa, Mika
AU - Itoh, Masumi
AU - Katayama, Toshiaki
AU - Kawashima, Shuichi
AU - Okuda, Shujiro
AU - Tokimatsu, Toshiaki
AU - Yamanishi, Yoshihiro
N1 - Funding Information:
THE KEGG project is supported by the Institute for Bioinformatics Research and Development of the Japan Science and Technology Agency, the 21st Century COE program ‘Genome Science’, and a grant-in-aid for scientific research on the priority area ‘Comprehensive Genomics’ from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The computational resource was provided by the Bioinformatics Center, Institute for Chemical Research, Kyoto University. Funding to pay the Open Access publication charges for this article was provided by the grant-in-aid for scientific research.
PY - 2008/1
Y1 - 2008/1
N2 - KEGG (http://www.genome.jp/kegg/) is a database of biological systems that integrates genomic, chemical and systemic functional information. KEGG provides a reference knowledge base for linking genomes to life through the process of PATHWAY mapping, which is to map, for example, a genomic or transcriptomic content of genes to KEGG reference pathways to infer systemic behaviors of the cell or the organism. In addition, KEGG provides a reference knowledge base for linking genomes to the environment, such as for the analysis of drug-target relationships, through the process of BRITE mapping. KEGG BRITE is an ontology database representing functional hierarchies of various biological objects, including molecules, cells, organisms, diseases and drugs, as well as relationships among them. KEGG PATHWAY is now supplemented with a new global map of metabolic pathways, which is essentially a combined map of about 120 existing pathway maps. In addition, smaller pathway modules are defined and stored in KEGG MODULE that also contains other functional units and complexes. The KEGG resource is being expanded to suit the needs for practical applications. KEGG DRUG contains all approved drugs in the US and Japan, and KEGG DISEASE is a new database linking disease genes, pathways, drugs and diagnostic markers.
AB - KEGG (http://www.genome.jp/kegg/) is a database of biological systems that integrates genomic, chemical and systemic functional information. KEGG provides a reference knowledge base for linking genomes to life through the process of PATHWAY mapping, which is to map, for example, a genomic or transcriptomic content of genes to KEGG reference pathways to infer systemic behaviors of the cell or the organism. In addition, KEGG provides a reference knowledge base for linking genomes to the environment, such as for the analysis of drug-target relationships, through the process of BRITE mapping. KEGG BRITE is an ontology database representing functional hierarchies of various biological objects, including molecules, cells, organisms, diseases and drugs, as well as relationships among them. KEGG PATHWAY is now supplemented with a new global map of metabolic pathways, which is essentially a combined map of about 120 existing pathway maps. In addition, smaller pathway modules are defined and stored in KEGG MODULE that also contains other functional units and complexes. The KEGG resource is being expanded to suit the needs for practical applications. KEGG DRUG contains all approved drugs in the US and Japan, and KEGG DISEASE is a new database linking disease genes, pathways, drugs and diagnostic markers.
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U2 - 10.1093/nar/gkm882
DO - 10.1093/nar/gkm882
M3 - Article
C2 - 18077471
AN - SCOPUS:38549126643
SN - 0305-1048
VL - 36
SP - D480-D484
JO - Nucleic acids research
JF - Nucleic acids research
IS - SUPPL. 1
ER -