TY - JOUR
T1 - Kawasaki disease and vaccination
T2 - Prospective case-control and case-crossover studies among infants in japan
AU - Murata, Kenji
AU - Onoyama, Sagano
AU - Yamamura, Kenichiro
AU - Mizuno, Yumi
AU - Furuno, Kenji
AU - Matsubara, Keita
AU - Hatae, Ken
AU - Masuda, Kiminori
AU - Nomura, Yuichi
AU - Ohno, Takuro
AU - Kinumaki, Akiko
AU - Miura, Masaru
AU - Sakai, Yasunari
AU - Ohga, Shouichi
AU - Fukushima, Wakaba
AU - Kishimoto, Junji
AU - Nakamura, Yosikazu
AU - Hara, Toshiro
N1 - Funding Information:
Funding: This research was funded by a Fukuoka Children’s Hospital Research Grant.
Funding Information:
This research was funded by a Fukuoka Children?s Hospital Research Grant.Acknowledgments: We thank Manao Nishimura, Takuya Oda, Yasutaka Nakashima, Yui Takada, and Eiji Kubo (Department of Pediatrics, Japanese Red Cross Fukuoka Hospital), Takuya Hara (De-partment of Pediatrics, Oita Prefectural Hospital), and Kotomi Chikama and Naohiro Suga (Depart-ment of Pediatrics, National Hospital Organization Fukuoka Higashi Medical Center) for providing detailed information of the patients through the questionnaire and asking the patient?s parents to complete the questionnaire. We also thank Hiroko Watanabe (Center for Clinical and Translational Research, Kyushu University Hospital) for supporting the statistical analysis. We appreciate the help of Brian Quinn (Japan Medical Communication, Fukuoka, Japan) in editing the manuscript.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/8
Y1 - 2021/8
N2 - The causal effects of vaccines on Kawasaki disease (KD) remain elusive. We aimed to examine the association between vaccines administered during infancy and the development of KD in Japan. We conducted a multicenter prospective case-control study using questionnaires and compared the vaccination status of infants (age: 6 weeks to 9 months) who developed KD (KD group; n = 102) and those who did not develop KD (non-KD group; n = 139). Next, we performed a case-crossover study of 98 cases in the KD group and compared the status of vaccinations between the case and control periods. We also compared the incidence of KD in children for each 5-year period before and after the addition of new vaccines (2012–2013) using data from the Nationwide Survey of KD. In the case-control study, the vaccination status of the KD and control groups did not differ to a statistically significant extent. Multivariable analysis of the vaccination status and patient back-grounds showed no significant association between vaccination and KD development. In the case-crossover study, the status of vaccinations during the case and control periods did not differ to a statistically significant extent. In the analysis of data from the Nationwide Survey of KD, the incidence of KD in children of ages subject to frequent vaccination showed no significant increases in the latter five years, 2014–2018. Based on these prospective analyses, we confirmed that vaccination in early infancy did not affect the risk of KD.
AB - The causal effects of vaccines on Kawasaki disease (KD) remain elusive. We aimed to examine the association between vaccines administered during infancy and the development of KD in Japan. We conducted a multicenter prospective case-control study using questionnaires and compared the vaccination status of infants (age: 6 weeks to 9 months) who developed KD (KD group; n = 102) and those who did not develop KD (non-KD group; n = 139). Next, we performed a case-crossover study of 98 cases in the KD group and compared the status of vaccinations between the case and control periods. We also compared the incidence of KD in children for each 5-year period before and after the addition of new vaccines (2012–2013) using data from the Nationwide Survey of KD. In the case-control study, the vaccination status of the KD and control groups did not differ to a statistically significant extent. Multivariable analysis of the vaccination status and patient back-grounds showed no significant association between vaccination and KD development. In the case-crossover study, the status of vaccinations during the case and control periods did not differ to a statistically significant extent. In the analysis of data from the Nationwide Survey of KD, the incidence of KD in children of ages subject to frequent vaccination showed no significant increases in the latter five years, 2014–2018. Based on these prospective analyses, we confirmed that vaccination in early infancy did not affect the risk of KD.
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U2 - 10.3390/vaccines9080839
DO - 10.3390/vaccines9080839
M3 - Article
AN - SCOPUS:85111627814
SN - 2076-393X
VL - 9
JO - Vaccines
JF - Vaccines
IS - 8
M1 - 839
ER -
