Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats

Nobuaki Egashira, Naomi Manome, Kouji Kurauchi, Yoshiaki Matsumoto, Katsunori Iwasaki, Kenichi Mishima, Yukihiro Shoyama, Michihiro Fujiwara

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13 Citations (Scopus)


The present study investigated the effects of Kamikihi-to (KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight-arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, and Δ9-tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine-induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC-induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalPhytotherapy Research
Issue number2
Publication statusPublished - Feb 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology


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