TY - JOUR
T1 - Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats
AU - Egashira, Nobuaki
AU - Manome, Naomi
AU - Kurauchi, Kouji
AU - Matsumoto, Yoshiaki
AU - Iwasaki, Katsunori
AU - Mishima, Kenichi
AU - Shoyama, Yukihiro
AU - Fujiwara, Michihiro
PY - 2007/2
Y1 - 2007/2
N2 - The present study investigated the effects of Kamikihi-to (KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight-arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, and Δ9-tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine-induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC-induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits.
AB - The present study investigated the effects of Kamikihi-to (KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight-arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, and Δ9-tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine-induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC-induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits.
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U2 - 10.1002/ptr.2034
DO - 10.1002/ptr.2034
M3 - Article
C2 - 17117451
AN - SCOPUS:33847002012
SN - 0951-418X
VL - 21
SP - 126
EP - 129
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 2
ER -