TY - JOUR
T1 - Japan’s RIKEN BSI
T2 - Whole facility chlorine dioxide gas decontamination approach for a barrier facility—A case study
AU - Takahashi, Eiki
AU - Czarneski, Mark A.
AU - Sugiura, Akihoki
N1 - Funding Information:
The latest-generation fumigant is CD gas. One of the benefits of CD gas is that it is a true gas at room temperature. It has been used for a long time in studies (Han, 2000; Jeng, 1990), isolators (Czarneski, 2008; Eylath, 2003), processing vessels (Eylath, 2003b), juice tanks (Han, 1999), HEPA housings with small tubing (Devine, 2009), biological safety cabinets (BSCs) (Luftman, 2008a; NSF International, 2008), rooms (Leo, 2005; Sawyer, 2010), and large facilities (Czarneski, 2007; Luftman, 2008b). It is a gas at room temperature (boiling point 11ºC) like formaldehyde, and is not considered to be carcinogenic by the International Agency for Research on Cancer (IARC), Network Time Protocol (NTP), the Occupational Safety and Health Association (OSHA), or the American Council of Governmental Industrial Hygiene (ACGIH).
Publisher Copyright:
© 2017, SAGE Publications Inc. All rights reserved.
PY - 2014/12
Y1 - 2014/12
N2 - This article discusses one of Japan’s newest research facilities—the RIKEN Brain Science Institute. The Brain Science Institute (BSI) conducts research that integrates multiple disciplines including medicine, biology, psychology, physics, computer science, and technology, and utilizes several different rodent models in a clean barrier facility. This article discusses the specific layout of the BSI barrier facility, the cleaning procedure used, and the decontamination process that uses chlorine dioxide (CD) gas as a replacement for formaldehyde gas. Diagrams show gas generator injection and sample locations, as well as fan locations. In addition, this article briefly compares the process of using CD gas to other methods of decontamination. Since CD was successful in the decontamination, the entire barrier facility now uses it to maintain the same level of cleanliness that was obtained in the initial process.
AB - This article discusses one of Japan’s newest research facilities—the RIKEN Brain Science Institute. The Brain Science Institute (BSI) conducts research that integrates multiple disciplines including medicine, biology, psychology, physics, computer science, and technology, and utilizes several different rodent models in a clean barrier facility. This article discusses the specific layout of the BSI barrier facility, the cleaning procedure used, and the decontamination process that uses chlorine dioxide (CD) gas as a replacement for formaldehyde gas. Diagrams show gas generator injection and sample locations, as well as fan locations. In addition, this article briefly compares the process of using CD gas to other methods of decontamination. Since CD was successful in the decontamination, the entire barrier facility now uses it to maintain the same level of cleanliness that was obtained in the initial process.
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U2 - 10.1177/153567601401900404
DO - 10.1177/153567601401900404
M3 - Article
AN - SCOPUS:85022336800
SN - 1535-6760
VL - 19
SP - 201
EP - 210
JO - Applied Biosafety
JF - Applied Biosafety
IS - 4
ER -
