Japanese Dermatological Association Guidelines: Outlines of guidelines for cutaneous melanoma 2019

Yasuhiro Nakamura, Jun Asai, Hiroshi Igaki, Takashi Inozume, Kenjiro Namikawa, Ayato Hayashi, Satoshi Fukushima, Taku Fujimura, Takamichi Ito, Keisuke Imafuku, Ryota Tanaka, Yukiko Teramoto, Akane Minagawa, Takuya Miyagawa, Azusa Miyashita, Makoto Wada, Hiroshi Koga, Makoto Sugaya

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


With consideration of the ongoing developments in treatment options for cutaneous melanoma, the Japanese Skin Cancer Society published the first guidelines for cutaneous melanoma in 2007 and later revised them in 2015. Here, we report on an English version of the 2019 Japanese Melanoma Guidelines. In this latest edition, all processes were carried out according to the Grading of Recommendations, Assessment, Development and Evaluation system. A comprehensive published work search, systematic review and determination of recommendations in each clinical question were performed by a multidisciplinary expert panel consisting of dermatologists, a plastic and reconstructive surgeon, and a radiation oncologist. The advent of novel agents, such as immune checkpoint inhibitors and molecular-targeted agents, has drastically changed the nature of treatment for adjuvant and advanced-stage diseases among melanoma patients worldwide. Additionally, recent reports of clinical trials regarding surgical procedures and a better understanding of molecular biology and tumor immunology in clinical types of melanoma have had an impact on clinical practise. Based on these viewpoints, eight relevant clinical questions were raised in this report that aim to help clinicians select the appropriate therapeutic approach.

Original languageEnglish
Pages (from-to)89-103
Number of pages15
JournalJournal of Dermatology
Issue number2
Publication statusPublished - Feb 1 2020

All Science Journal Classification (ASJC) codes

  • Dermatology


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