Japanese clinical guidelines for autoimmune pancreatitis

Kazuichi Okazaki, Shigeyuki Kawa, Terumi Kamisawa, Tetsuhide Ito, Kazuo Inui, Hiroyuki Irie, Atsushi Irisawa, Keishi Kubo, Kenji Notohara, Osamu Hasebe, Yasunari Fujinaga, Hirotaka Ohara, Shigeki Tanaka, Takayoshi Nishino, Isao Nishimori, Toshimasa Nishiyama, Koichi Suda, Keiko Shiratori, Toru Shimosegawa, Masao Tanaka

Research output: Contribution to journalReview articlepeer-review

132 Citations (Scopus)


OBJECTIVES:: As the patients with autoimmune pancreatitis (AIP) are increasing in Japan, the practical guideline for managing AIP is required to be established. METHODS:: Three committees (the professional committee for making clinical questions [CQs] and statements by Japanese specialists, the expert panelist committee for rating statements by the modified Delphi method, and the evaluating committee by moderators) were organized. Fifteen specialists for AIP extracted the specific clinical statements from a total of 871 literatures by PubMed search (∼1963-2008) and from a secondary database and made the CQs and statements. The expert panelists individually rated these clinical statements using a modified Delphi approach, in which a clinical statement receiving a median score greater than 7 on a 9-point scale from the panel was regarded as valid. RESULTS:: The professional committee made 13, 6, 6, and 11 CQs and statements for the concept and diagnosis, extrapancreatic lesions, differential diagnosis, and treatment, respectively. The expert panelists regarded them as valid after a 2-round modified Delphi approach. CONCLUSIONS:: After evaluation by the moderators, the Japanese clinical guideline for AIP has been established. Further studies for the international guideline are needed after international consensus for diagnosis and treatment.

Original languageEnglish
Pages (from-to)849-866
Number of pages18
Issue number8
Publication statusPublished - Nov 2009

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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