TY - JOUR
T1 - Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells
T2 - Cytotoxicity and structural criteria
AU - Arung, Enos Tangke
AU - Yoshikawa, Keisuke
AU - Shimizu, Kuniyoshi
AU - Kondo, Ryuichiro
N1 - Funding Information:
This research was supported by the Japan Society for the Promotion of Science (JSPS) .
PY - 2010/3
Y1 - 2010/3
N2 - As a result of cytotoxicity-guided fractionation, nine flavonoids, artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5), albanin A (6), cudraflavone B (7), brosimone I (8) and artocarpanone (9) were identified from the methanol extract of the wood of Artocarpus heterophyllus, known commonly as Nangka in Indonesia. A structure-activity investigation of the effect of these isolated compounds (1-9) and structurally related compounds on B16 melanoma cells indicated that isoprenoid moiety substitutions in flavonoids enhance their cytotoxicity, and that the position of attachment and the number of isoprenoid-substituent moieties per molecule influence flavonoid cytotoxicity.
AB - As a result of cytotoxicity-guided fractionation, nine flavonoids, artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5), albanin A (6), cudraflavone B (7), brosimone I (8) and artocarpanone (9) were identified from the methanol extract of the wood of Artocarpus heterophyllus, known commonly as Nangka in Indonesia. A structure-activity investigation of the effect of these isolated compounds (1-9) and structurally related compounds on B16 melanoma cells indicated that isoprenoid moiety substitutions in flavonoids enhance their cytotoxicity, and that the position of attachment and the number of isoprenoid-substituent moieties per molecule influence flavonoid cytotoxicity.
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U2 - 10.1016/j.fitote.2009.08.001
DO - 10.1016/j.fitote.2009.08.001
M3 - Article
C2 - 19686821
AN - SCOPUS:72249094582
SN - 0367-326X
VL - 81
SP - 120
EP - 123
JO - Fitoterapia
JF - Fitoterapia
IS - 2
ER -