Isolation of a new antitumor substance from Bacillus stearothermophilus.

Yasuhiro Kohama; Tetsuyuki Teramoto; Kentaro Iida; Norihito Murayama; Taro Samba; Noriko Tatebatake; Yuzo Kayamori; Kazutake Tsujikawa; Tsutomu Mimura

doi:10.1248/cpb.39.2468

Isolation of a new antitumor substance from Bacillus stearothermophilus.

Yasuhiro Kohama, Tetsuyuki Teramoto, Kentaro Iida, Norihito Murayama, Taro Samba, Noriko Tatebatake, Yuzo Kayamori, Kazutake Tsujikawa, Tsutomu Mimura

Division of Medical Technology

Research output: Contribution to journal › Article › peer-review

Abstract

A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC50 : 4μg/ml) and mouse mastocytoma, P-815 (IC50 : 0.6μg/ml), but not that of Balb/c 3T3.

Original language	English
Pages (from-to)	2468-2470
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	39
Issue number	9
DOIs	https://doi.org/10.1248/cpb.39.2468
Publication status	Published - 1991

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title = "Isolation of a new antitumor substance from Bacillus stearothermophilus.",

abstract = "A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC50 : 4μg/ml) and mouse mastocytoma, P-815 (IC50 : 0.6μg/ml), but not that of Balb/c 3T3.",

author = "Yasuhiro Kohama and Tetsuyuki Teramoto and Kentaro Iida and Norihito Murayama and Taro Samba and Noriko Tatebatake and Yuzo Kayamori and Kazutake Tsujikawa and Tsutomu Mimura",

year = "1991",

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T1 - Isolation of a new antitumor substance from Bacillus stearothermophilus.

AU - Kohama, Yasuhiro

AU - Teramoto, Tetsuyuki

AU - Iida, Kentaro

AU - Murayama, Norihito

AU - Samba, Taro

AU - Tatebatake, Noriko

AU - Kayamori, Yuzo

AU - Tsujikawa, Kazutake

AU - Mimura, Tsutomu

PY - 1991

Y1 - 1991

N2 - A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC50 : 4μg/ml) and mouse mastocytoma, P-815 (IC50 : 0.6μg/ml), but not that of Balb/c 3T3.

AB - A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC50 : 4μg/ml) and mouse mastocytoma, P-815 (IC50 : 0.6μg/ml), but not that of Balb/c 3T3.

U2 - 10.1248/cpb.39.2468

DO - 10.1248/cpb.39.2468

M3 - Article

SN - 0009-2363

VL - 39

SP - 2468

EP - 2470

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 9

ER -

Isolation of a new antitumor substance from Bacillus stearothermophilus.

Abstract

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