Isolation of a new antitumor substance from Bacillus stearothermophilus.

Yasuhiro Kohama, Tetsuyuki Teramoto, Kentaro Iida, Norihito Murayama, Taro Samba, Noriko Tatebatake, Yuzo Kayamori, Kazutake Tsujikawa, Tsutomu Mimura

Research output: Contribution to journalArticlepeer-review


A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC<SUB>50</SUB> : 4μg/ml) and mouse mastocytoma, P-815 (IC<SUB>50</SUB> : 0.6μg/ml), but not that of Balb/c 3T3.
Original languageEnglish
Pages (from-to)2468-2470
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - 1991


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