Isolation and structure of three new ceramides from the starfish Acanthaster planci

Masanori Inagaki, Ryuichi Isobe, Yasuhiro Kawano, Tomofumi Miyamoto, Tetsuya Komori, Ryuichi Higuchi

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


Three new phytosphingosine-type ceramides, AC-1-6, AC-1-10 and AC-1-11, were isolated from the ceramide molecular species AC-1, obtained from the less polar fraction of the CHCl3/MeOH extract of the starfish Acanthaster planci. The structures of these ceramides were determined on the basis of chemical and spectroscopic evidence as (2S,2′ R,3S,4R,9Z)-2-(2-hydroxyhexadecanoylamino)-9-docosene-1,3,4-triol (AC-1-6), (2S,2′ R,3S,4R,)-2-(2-hydroxytricosanoylamino)hexadecane-1,3,4-triol (AC-1-10) and (2S,2′ R,3S,4R,)-2(2-hydroxytetracosanoylamino)hexadecane-1,3,4-triol (AC-1-11). Positive ion FABMS/MS of each ceramide gave important information for their structure elucidation. Mass spectrometry of the dimethyl disulfide derivatives of ceramide was also useful for the determination of the double bond position in the long-chain base.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalEuropean Journal of Organic Chemistry
Issue number1
Publication statusPublished - Jan 1998

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Isolation and structure of three new ceramides from the starfish Acanthaster planci'. Together they form a unique fingerprint.

Cite this