Isolated metastasis to the gallbladder from hepatocellular carcinoma

Masahiro Murakami; Shogo Kobayashi; Shigeru Marubashi; Hidetoshi Eguchi; Yutaka Takeda; Masahiro Tanemura; Hiroshi Wada; Koji Umeshita; Wakasa Kennichi; Yuichiro Doki; Masaki Mori; Hiroaki Nagano

doi:10.1111/j.1872-034X.2010.00689.x

Isolated metastasis to the gallbladder from hepatocellular carcinoma

Masahiro Murakami, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Yutaka Takeda, Masahiro Tanemura, Hiroshi Wada, Koji Umeshita, Wakasa Kennichi, Yuichiro Doki, Masaki Mori, Hiroaki Nagano

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Aim: Metastasis to gallbladder (GB) from hepatocellular carcinoma (HCC) is rare, and it is difficult to determine indications for surgery. We report eight cases of synchronous isolated GB metastasis, and analyze their features retrospectively. Methods: Among 439 HCC patients who underwent hepatectomy from 1998 to 2008 at our institution, 393 (89.5%) underwent concurrent cholecystectomy. Results: Among them, eight (1.8%) had GB metastasis without other distant metastases. None of these cases showed evidence of direct invasion. All cases had advanced portal vein thrombus (PVTT) and their main tumor located near the GB bed. Five cases had apparent tumor mass in the GB wall, and the other three cases had only tumor thrombus in the GB veins. Six cases were treated postoperatively with local infusion therapy with interferon, and three of them showed long-term survival. Conclusion: Our eight cases of GB metastasis from HCC were closely related to PVTT. Surgical resection and multimodal treatment would be necessary for long-term survival in cases with isolated GB metastasis.

Original language	English
Pages (from-to)	793-798
Number of pages	6
Journal	Hepatology Research
Volume	40
Issue number	8
DOIs	https://doi.org/10.1111/j.1872-034X.2010.00689.x
Publication status	Published - Aug 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hepatology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1872-034X.2010.00689.x

Cite this

@article{4ce9ddb78e4e4444b7bc6ab0b2606ebd,

title = "Isolated metastasis to the gallbladder from hepatocellular carcinoma",

abstract = "Aim: Metastasis to gallbladder (GB) from hepatocellular carcinoma (HCC) is rare, and it is difficult to determine indications for surgery. We report eight cases of synchronous isolated GB metastasis, and analyze their features retrospectively. Methods: Among 439 HCC patients who underwent hepatectomy from 1998 to 2008 at our institution, 393 (89.5%) underwent concurrent cholecystectomy. Results: Among them, eight (1.8%) had GB metastasis without other distant metastases. None of these cases showed evidence of direct invasion. All cases had advanced portal vein thrombus (PVTT) and their main tumor located near the GB bed. Five cases had apparent tumor mass in the GB wall, and the other three cases had only tumor thrombus in the GB veins. Six cases were treated postoperatively with local infusion therapy with interferon, and three of them showed long-term survival. Conclusion: Our eight cases of GB metastasis from HCC were closely related to PVTT. Surgical resection and multimodal treatment would be necessary for long-term survival in cases with isolated GB metastasis.",

author = "Masahiro Murakami and Shogo Kobayashi and Shigeru Marubashi and Hidetoshi Eguchi and Yutaka Takeda and Masahiro Tanemura and Hiroshi Wada and Koji Umeshita and Wakasa Kennichi and Yuichiro Doki and Masaki Mori and Hiroaki Nagano",

year = "2010",

month = aug,

doi = "10.1111/j.1872-034X.2010.00689.x",

language = "English",

volume = "40",

pages = "793--798",

journal = "Hepatology Research",

issn = "1386-6346",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Isolated metastasis to the gallbladder from hepatocellular carcinoma

AU - Murakami, Masahiro

AU - Kobayashi, Shogo

AU - Marubashi, Shigeru

AU - Eguchi, Hidetoshi

AU - Takeda, Yutaka

AU - Tanemura, Masahiro

AU - Wada, Hiroshi

AU - Umeshita, Koji

AU - Kennichi, Wakasa

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Nagano, Hiroaki

PY - 2010/8

Y1 - 2010/8

N2 - Aim: Metastasis to gallbladder (GB) from hepatocellular carcinoma (HCC) is rare, and it is difficult to determine indications for surgery. We report eight cases of synchronous isolated GB metastasis, and analyze their features retrospectively. Methods: Among 439 HCC patients who underwent hepatectomy from 1998 to 2008 at our institution, 393 (89.5%) underwent concurrent cholecystectomy. Results: Among them, eight (1.8%) had GB metastasis without other distant metastases. None of these cases showed evidence of direct invasion. All cases had advanced portal vein thrombus (PVTT) and their main tumor located near the GB bed. Five cases had apparent tumor mass in the GB wall, and the other three cases had only tumor thrombus in the GB veins. Six cases were treated postoperatively with local infusion therapy with interferon, and three of them showed long-term survival. Conclusion: Our eight cases of GB metastasis from HCC were closely related to PVTT. Surgical resection and multimodal treatment would be necessary for long-term survival in cases with isolated GB metastasis.

AB - Aim: Metastasis to gallbladder (GB) from hepatocellular carcinoma (HCC) is rare, and it is difficult to determine indications for surgery. We report eight cases of synchronous isolated GB metastasis, and analyze their features retrospectively. Methods: Among 439 HCC patients who underwent hepatectomy from 1998 to 2008 at our institution, 393 (89.5%) underwent concurrent cholecystectomy. Results: Among them, eight (1.8%) had GB metastasis without other distant metastases. None of these cases showed evidence of direct invasion. All cases had advanced portal vein thrombus (PVTT) and their main tumor located near the GB bed. Five cases had apparent tumor mass in the GB wall, and the other three cases had only tumor thrombus in the GB veins. Six cases were treated postoperatively with local infusion therapy with interferon, and three of them showed long-term survival. Conclusion: Our eight cases of GB metastasis from HCC were closely related to PVTT. Surgical resection and multimodal treatment would be necessary for long-term survival in cases with isolated GB metastasis.

UR - http://www.scopus.com/inward/record.url?scp=77955266129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955266129&partnerID=8YFLogxK

U2 - 10.1111/j.1872-034X.2010.00689.x

DO - 10.1111/j.1872-034X.2010.00689.x

M3 - Article

C2 - 20649819

AN - SCOPUS:77955266129

SN - 1386-6346

VL - 40

SP - 793

EP - 798

JO - Hepatology Research

JF - Hepatology Research

IS - 8

ER -

Isolated metastasis to the gallbladder from hepatocellular carcinoma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this