TY - JOUR
T1 - Irciniasulfonic acid B, a novel taurine conjugated fatty acid derivative from a Japanese marine sponge, Ircinia sp.
AU - Emura, Chisato
AU - Higuchi, Ryuichi
AU - Miyamoto, Tomofumi
N1 - Funding Information:
We would like to thank Mr. M. Kinoshita and the late Captain Y. Shichida of the Fishery Research Laboratory, Kyushu University, for collection of the marine sponge. We also wish to thank Professor M. Kobayashi, Dr. S. Aoki, and Dr. N. Kotoku of Graduate School of Pharmaceutical Sciences, Osaka University for providing HR-ESI TOFMS data. This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas 40182050 from The Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.
PY - 2006/6/12
Y1 - 2006/6/12
N2 - Irciniasulfonic acid B (1) was obtained from a marine sponge, Ircinia sp., together with a known multi-drug resistance modulator irciniasulfonic acid (2). Spectroscopic and chemical analyses revealed structure consisting of common unsaturated fatty acids, a novel unsaturated branched fatty acid, and a taurine. Final separation of irciniasulfonic acid B (1) was achieved with its methylated derivatives. Irciniasulfonic acid B (1) reversed the multi-drug resistance in the same way as irciniasulfonic acid.
AB - Irciniasulfonic acid B (1) was obtained from a marine sponge, Ircinia sp., together with a known multi-drug resistance modulator irciniasulfonic acid (2). Spectroscopic and chemical analyses revealed structure consisting of common unsaturated fatty acids, a novel unsaturated branched fatty acid, and a taurine. Final separation of irciniasulfonic acid B (1) was achieved with its methylated derivatives. Irciniasulfonic acid B (1) reversed the multi-drug resistance in the same way as irciniasulfonic acid.
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U2 - 10.1016/j.tet.2006.03.087
DO - 10.1016/j.tet.2006.03.087
M3 - Article
AN - SCOPUS:33646348701
SN - 0040-4020
VL - 62
SP - 5682
EP - 5685
JO - Tetrahedron
JF - Tetrahedron
IS - 24
ER -
