TY - JOUR
T1 - Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior
T2 - Comparison with paroxetine
AU - Egashira, Nobuaki
AU - Harada, Satoko
AU - Okuno, Ryoko
AU - Matsushita, Michihiko
AU - Nishimura, Ryoji
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Orito, Kensuke
AU - Fujiwara, Michihiro
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 18591318). We thank Solvay Pharmaceutical (Tokyo, Japan) and GlaxoSmithKline (West Sussex, UK) for generously donating the fluvoxamine and paroxetine used in this study.
PY - 2007/6/1
Y1 - 2007/6/1
N2 - In the present study, we examined the involvement of the sigma1 receptor in the inhibitory effect of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine, compared with that of paroxetine, on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Sigma1 receptor agonists (+)-SKF 10047 and PRE-084 significantly inhibited marble-burying behavior. Sigma receptor antagonist BD 1047 and selective sigma1 receptor antagonist BD 1063 significantly attenuated the inhibition of marble-burying behavior by fluvoxamine. In contrast, selective sigma2 receptor antagonist SM-21 failed to affect the inhibition of marble-burying behavior by fluvoxamine. On the other hand, BD 1047 and BD 1063 had no effect on the inhibition of marble-burying behavior by paroxetine. These observations show that activation of the sigma1 receptor is a necessary component in the inhibitory effect of fluvoxamine on marble-burying behavior, and that the mechanism of its action is clearly different from that of paroxetine.
AB - In the present study, we examined the involvement of the sigma1 receptor in the inhibitory effect of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine, compared with that of paroxetine, on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Sigma1 receptor agonists (+)-SKF 10047 and PRE-084 significantly inhibited marble-burying behavior. Sigma receptor antagonist BD 1047 and selective sigma1 receptor antagonist BD 1063 significantly attenuated the inhibition of marble-burying behavior by fluvoxamine. In contrast, selective sigma2 receptor antagonist SM-21 failed to affect the inhibition of marble-burying behavior by fluvoxamine. On the other hand, BD 1047 and BD 1063 had no effect on the inhibition of marble-burying behavior by paroxetine. These observations show that activation of the sigma1 receptor is a necessary component in the inhibitory effect of fluvoxamine on marble-burying behavior, and that the mechanism of its action is clearly different from that of paroxetine.
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U2 - 10.1016/j.ejphar.2007.02.019
DO - 10.1016/j.ejphar.2007.02.019
M3 - Article
C2 - 17349995
AN - SCOPUS:34247134612
SN - 0014-2999
VL - 563
SP - 149
EP - 154
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -