TY - JOUR
T1 - Involvement of neuronal cell surface molecule B2 in the formation of retinal plexiform layers
AU - Ohta, Kunimasa
AU - Takagi, Shin
AU - Asou, Hiroaki
AU - Fujisawa, Hajime
N1 - Funding Information:
We wish to thank Dr. Urs Rutishauser (Case Western Reserve University) for providing the antibody to frog N-CAM and Dr. Fumio Tokunaga (Tohoku University) for the monoclonal antibody to rhodopsin. We also thank Dr. Mitsumasa Okamoto and Mr. Akihiko Simon0 (Nagoya University) for providing facilities for Ultracut sectioning and microscopy. This work was supported by grants from the Ministry of Education, Science and Culture, Japan, the Mitsubishi Foundation, and the Naito Foundation and by the special coordination funds of the Science and Technology Agency of the Japanese Government.
PY - 1992/7
Y1 - 1992/7
N2 - The B2 molecule is a 220 kd neuronal cell surface protein of Xenopus, recognized by monoclonal antibody B2 (MAb B2). Immunohistochemistry using MAb B2 revealed that the B2 molecule was expessed in both the inner and outer plexiform layers within the neural retina. During development of the neural retina, the B2 molecule first appeared at stages 35 36 in the newly formed plexiform layers. When embryonic eyes were cultured in the presence of anti-B2 antiserum (Fab fragments), the formation of the retinal plexiform layers was impeded. These data suggest that the cell surface molecule B2 plays a role in the development of retinal plexiform layers.
AB - The B2 molecule is a 220 kd neuronal cell surface protein of Xenopus, recognized by monoclonal antibody B2 (MAb B2). Immunohistochemistry using MAb B2 revealed that the B2 molecule was expessed in both the inner and outer plexiform layers within the neural retina. During development of the neural retina, the B2 molecule first appeared at stages 35 36 in the newly formed plexiform layers. When embryonic eyes were cultured in the presence of anti-B2 antiserum (Fab fragments), the formation of the retinal plexiform layers was impeded. These data suggest that the cell surface molecule B2 plays a role in the development of retinal plexiform layers.
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U2 - 10.1016/0896-6273(92)90230-B
DO - 10.1016/0896-6273(92)90230-B
M3 - Article
C2 - 1632969
AN - SCOPUS:0026637781
SN - 0896-6273
VL - 9
SP - 151
EP - 161
JO - Neuron
JF - Neuron
IS - 1
ER -