TY - JOUR
T1 - Involvement of insulin-like growth factor-1 in the effect of caloric restriction
T2 - Regulation of plasma adiponectin and leptin
AU - Yamaza, Haruyoshi
AU - Komatsu, Toshimitsu
AU - To, Kazuo
AU - Toyama, Hiroaki
AU - Chiba, Takuya
AU - Higami, Yoshikazu
AU - Shimokawa, Isao
N1 - Funding Information:
ACKNOWLEDGMENTS This work was supported by a Grant-in-Aid for Science Research from the Japan Society for the Promotion of Sciences (15390128). rhIGF-1 was donated by Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
PY - 2007/1
Y1 - 2007/1
N2 - Insulin-like growth factor (IGF)-1 signaling might partly mediate effects of caloric restriction (CR), an experimental intervention for increasing longevity in mammals. The present study evaluated effects of recombinant human (rh)IGF-1 infusion on adipokine levels in CR and transgenic (Tg) dwarf rats with the reduced growth hormone-IGF-1 axis, which shared similar body weight and food intake. At 9 months of age, each rat received a continuous infusion of rhIGF-1 for 14 days, and rats received an injection of glucose after overnight fasting. Infusion of rhIGF-1 had metabolic effects in all rat groups although it did not affect insulin sensitivity in any of the groups. In addition, plasma adiponectin was decreased to the control group levels and plasma leptin was further reduced in CR and Tg rats. The similarity of phenotypes and adipokine responses to rhIGF-1 between CR and Tg rats supports a role for reduced IGF-1 signaling in the CR effect.
AB - Insulin-like growth factor (IGF)-1 signaling might partly mediate effects of caloric restriction (CR), an experimental intervention for increasing longevity in mammals. The present study evaluated effects of recombinant human (rh)IGF-1 infusion on adipokine levels in CR and transgenic (Tg) dwarf rats with the reduced growth hormone-IGF-1 axis, which shared similar body weight and food intake. At 9 months of age, each rat received a continuous infusion of rhIGF-1 for 14 days, and rats received an injection of glucose after overnight fasting. Infusion of rhIGF-1 had metabolic effects in all rat groups although it did not affect insulin sensitivity in any of the groups. In addition, plasma adiponectin was decreased to the control group levels and plasma leptin was further reduced in CR and Tg rats. The similarity of phenotypes and adipokine responses to rhIGF-1 between CR and Tg rats supports a role for reduced IGF-1 signaling in the CR effect.
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U2 - 10.1093/gerona/62.1.27
DO - 10.1093/gerona/62.1.27
M3 - Article
C2 - 17301034
AN - SCOPUS:34047113944
SN - 1079-5006
VL - 62
SP - 27
EP - 33
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 1
ER -