Involvement of caveolin-2 in caveolar biogenesis in MDCK cells

Ulla Lahtinen, Masanori Honsho, Robert G. Parton, Kai Simons, Paul Verkade

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


Caveolins have been identified as key components of caveolae, specialized cholesterol-enriched raft domains visible as small flask-shaped invaginations of the plasma membrane. In polarized MDCK cells caveolin-1 and -2 are found together on basolateral caveolae whereas the apical membrane, where only caveolin-1 is present, lacks caveolae. Expression of a caveolin mutant prevented the formation of the large caveolin-1/-2 hetero-oligomeric complexes, and led to intracellular retention of caveolin-2 and disappearance of caveolae from the basolateral membrane. Correspondingly, in MDCK cells over-expressing caveolin-2 the basolateral membrane exhibited an increased number of caveolae. These results indicate the involvement of caveolin-2 in caveolar biogenesis.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalFEBS Letters
Issue number1-3
Publication statusPublished - Mar 13 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


Dive into the research topics of 'Involvement of caveolin-2 in caveolar biogenesis in MDCK cells'. Together they form a unique fingerprint.

Cite this