Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia

Keiichi Irie; Kenichi Mishima; Daisuke Ishibashi; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara

doi:10.1016/S0024-3205(02)02270-1

Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia

Keiichi Irie, Kenichi Mishima, Daisuke Ishibashi, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

In the present study, we examined the effects of repeated ischemia (10 min × 2, 1 hr interval) on spatial memory in rats in an 8-arm radial maze test compared with single ischemia (10 min × 1). Repeated ischemia produced more severe impairment of spatial memory and stronger TUNEL-positive immunoreactivity in the hippocampal CA1 region than single ischemia at 7 days after reperfusion. Moreover, repeated ischemia altered bcl-family expression, which is related to apoptosis, while this was not affected by single ischemia. These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells.

Original language	English
Pages (from-to)	621-629
Number of pages	9
Journal	Life Sciences
Volume	72
Issue number	4-5
DOIs	https://doi.org/10.1016/S0024-3205(02)02270-1
Publication status	Published - Dec 20 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(02)02270-1

Cite this

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title = "Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia",

abstract = "In the present study, we examined the effects of repeated ischemia (10 min × 2, 1 hr interval) on spatial memory in rats in an 8-arm radial maze test compared with single ischemia (10 min × 1). Repeated ischemia produced more severe impairment of spatial memory and stronger TUNEL-positive immunoreactivity in the hippocampal CA1 region than single ischemia at 7 days after reperfusion. Moreover, repeated ischemia altered bcl-family expression, which is related to apoptosis, while this was not affected by single ischemia. These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells.",

author = "Keiichi Irie and Kenichi Mishima and Daisuke Ishibashi and Nobuaki Egashira and Katsunori Iwasaki and Michihiro Fujiwara",

note = "Funding Information: This study was supported in part by a Grant-in Aid for Scientific Research (No. 14572171) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Advanced Materials Institute of Fukuoka University and by a grant (No. 991001) from the Central Research Institute of Fukuoka University.",

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T1 - Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia

AU - Irie, Keiichi

AU - Mishima, Kenichi

AU - Ishibashi, Daisuke

AU - Egashira, Nobuaki

AU - Iwasaki, Katsunori

AU - Fujiwara, Michihiro

N1 - Funding Information: This study was supported in part by a Grant-in Aid for Scientific Research (No. 14572171) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Advanced Materials Institute of Fukuoka University and by a grant (No. 991001) from the Central Research Institute of Fukuoka University.

PY - 2002/12/20

Y1 - 2002/12/20

N2 - In the present study, we examined the effects of repeated ischemia (10 min × 2, 1 hr interval) on spatial memory in rats in an 8-arm radial maze test compared with single ischemia (10 min × 1). Repeated ischemia produced more severe impairment of spatial memory and stronger TUNEL-positive immunoreactivity in the hippocampal CA1 region than single ischemia at 7 days after reperfusion. Moreover, repeated ischemia altered bcl-family expression, which is related to apoptosis, while this was not affected by single ischemia. These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells.

AB - In the present study, we examined the effects of repeated ischemia (10 min × 2, 1 hr interval) on spatial memory in rats in an 8-arm radial maze test compared with single ischemia (10 min × 1). Repeated ischemia produced more severe impairment of spatial memory and stronger TUNEL-positive immunoreactivity in the hippocampal CA1 region than single ischemia at 7 days after reperfusion. Moreover, repeated ischemia altered bcl-family expression, which is related to apoptosis, while this was not affected by single ischemia. These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells.

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ER -

Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia

Abstract

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