Investigation of DNA strand exchange mechanisms mediated by cationic polymers.

Yuichi Sato, Won Jong Kim, Sung Won Choi, Minako Saito, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Research output: Contribution to journalArticlepeer-review


It was observed that conjugation of dextran for PLL provided PLL-g-Dex with new properties of enhancing and accelerating inter-nucleotide recognition (1, 2, 3). In this paper, we report the effects of cationic PLL-g-Dex copolymers on base-pair formation of self-complementary octamer oligonucleotide by using NMR and CD analysis. NMR studies revealed that PLL-g-Dex copolymer did not affect hydrogen-bondings between bases in DNA duplex. CD studies also supported inert nature of the copolymer upon hybrid structure.

Original languageEnglish
Pages (from-to)59-60
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
Publication statusPublished - 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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