Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver

Anthony Swain, Tomoko Inoue, Keai Sinn Tan, Yoichi Nakanishi, Daisuke Sugiyama

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


The fetal liver (FL) is an important structure in expansion and differentiation of hematopoietic stem cells (HSC), but despite this little is known about the exact mechanisms in which FL hematopoiesis takes place. Primitive hematopoiesis gives way to definitive hematopoiesis at 12.5 dpc in mice and the process is regulated by a number of intrinsic and extrinsic factors. Intrinsic regulations are intracellular processes that have been reported to be important in the initiation of definitive hematopoiesis. Several structures are involved with extrinsic regulations of hematopoiesis within the FL, including hepatoblasts and liver sinusoidal endothelial cells (LSEC). Hepatoblasts and endothelial cells comprise separate niches involved in the extrinsic regulation of hematopoiesis. Studies have shown that co-cultures with fetal liver stromal cells can promote the expansion of erythroid cells, although the way in which stromal cells do this is still unknown. Understanding the mechanisms in which hematopoiesis is regulated in the FL could lead to the production of novel therapies involving the safe and reliable transplantation of HSCs to patients with blood and bone marrow complications. This review aims to summarize the current state of knowledge about the regulation of hematopoiesis specifically within the FL.

Original languageEnglish
Pages (from-to)1077-1082
Number of pages6
JournalHistology and histopathology
Issue number9
Publication statusPublished - Sept 2014

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


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