[Intravital imaging of cancer cell dynamics].

Yoshinori Kagawa, Sakae Maeda, Masaki Mori, Masaru Ishii

Research output: Contribution to journalArticlepeer-review


Intravital imaging using two-photon laser scanning microscopy (TPSLM) can visualize the cellular dynamics in a living body. By recording spatiotemporal images, this technique allows the detection of unknown cell movements and related unknown phenomena in an environment in which blood circulation is maintained. Because of these advantages, this multidimensional in vivo analytical technique has attracted attention from various research fields. TPSLM has also been introduced in cancer research and utilized to visualize cancer cell movements. By determining cancer dynamics in vivo, it is expected that new cancer movement-related molecules will be discovered, which could be novel therapeutic targets. This article introduces the TPSLM imaging technique and method of molecular analysis using this imaging system.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalNihon Geka Gakkai zasshi
Issue number2
Publication statusPublished - Mar 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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