Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection

Eiichi Ogawa, Shigeru Otaguro, Masayuki Murata, Mosaburo Kainuma, Yasunori Sawayama, Norihiro Furusyo, Jun Hayashi

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22 Citations (Scopus)


Symptoms caused by acute human parvovirus B19 (HPV-B19) infection can vary considerably, from asymptomatic to severely symptomatic. A 39-year-old Japanese woman complained of sudden, severe arthralgia with edematous limbs coincident with an outbreak of HPV-B19 infection at the elementary school attended by her daughter. A diagnosis of acute HPV-B19 infection was made by the detection of serum antibody to HPV-B19 IgM and HPV-B19 DNA. Magnetic resonance imaging revealed bilateral synovitis of the cubital joints. The patient was immunocompetent and suffered from severe arthralgia associated with persistent HPV-B19 viremia for more than 4 months after the diagnosis of acute HPV-B19 infection. The administration of high-dose intravenous immunoglobulin resulted in remission, with little change in the serum HPV-B19 DNA level. Even in our immunocompetent patient, severe and prolonged arthritis was found to be associated with persistent viremia.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalJournal of Infection and Chemotherapy
Issue number5
Publication statusPublished - Oct 2008

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


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