Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer

Keisuke Ikeda, Eiji Oki, Hiroshi Saeki, Koji Ando, Masaru Morita, Yoshinao Oda, Masakazu Imamura, Yoshiniro Kakeji, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Aim: Vascular endothelial growth factor C (VEGFC) is thought to promote lymphangiogenesis in various human cancer tissues. Materials and Methods: The present study analyzed data from 72 patients with gastric cancer. The lymphatic vessel density (LVD) was determined by immunohistochemical staining using a monoclonal antibody (mAb) against D2-40, and the expression of VEGFC was investigated using a mAb against VEGFC. Results: The intratumoral LVD was higher in cases with nodal metastasis. The VEGFC-positive cases had a higher intratumoral LVD and were more invasive to the lymphatic vessels or lymph nodes than negative cases. Patients with VEGFC-positive cancer had significantly lower survival than those with negative cancer (p<0.05). Conclusion: The expression of VEGFC was related to intratumoral lymph angiogenesis and serves as a pertinent predictive factor for lymphatic invasion or metastasis, while also providing prognostic value.

Original languageEnglish
Pages (from-to)3911-3916
Number of pages6
JournalAnticancer research
Issue number8
Publication statusPublished - Aug 1 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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