TY - JOUR
T1 - Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease
AU - Ohga, S.
AU - Ikeuchi, K.
AU - Kadoya, R.
AU - Okada, K.
AU - Miyazaki, C.
AU - Suita, S.
AU - Ueda, K.
N1 - Funding Information:
This work was supported in part by a grant from the Ministry of Health and Welfare for Primary Immunodeficiency Diseases, and a Grant-in-Aid for the Encouragement of Young Scientists from the Ministry of Education Science and Culture of Japan. We are grateful to Dr Hiroyuki Nunoi (The Institute of Medical Science, The University of Tokyo, Tokyo) and Mr Mitsunobu Shimadzu (Mitsubishi Kagaku BCL, Tokyo) for the suggestions regarding the diagnosis of CGD.
PY - 1997
Y1 - 1997
N2 - A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O2- release and expression of NADPH oxidase components verified that he suffered from gp91-phox- chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.
AB - A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O2- release and expression of NADPH oxidase components verified that he suffered from gp91-phox- chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.
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U2 - 10.1016/S0163-4453(97)92509-3
DO - 10.1016/S0163-4453(97)92509-3
M3 - Article
C2 - 9138139
AN - SCOPUS:0030934530
SN - 0163-4453
VL - 34
SP - 147
EP - 150
JO - Journal of Infection
JF - Journal of Infection
IS - 2
ER -
