Intraosseous epithelioid hemangioendothelioma of the mandible: A case report with an immunohistochemical study

Hiroyuki Hamakawa, Takaaki Omori, Tomoki Sumida, Hiroaki Tanioka

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Epithelioid hemangioma is the prototype of a group of vascular tumors characterized by epithelioid endothelial cells. Hemangioendothelioma of bone is a rare lesion that constitutes less than 0.5% of primary malignant skeletal tumors. We report and discuss a case of epithelioid hemangioendothelioma arising intraosseously in the anterior portion of the mandible in a 76-year-old woman. The case was treated successfully by wide resection. Radiographically, the tumor mass showed osteolysis and expansion. Histologically, the tumor showed invasive and destructive growth, although it lacked frequent mitotic figures and severe atypia. On immunohistochemical study, tumor cells exhibited characteristics of mesenchymal and endothelial origin, i.e., strong to moderate immune reactivity against vimentin, factor VIII-related antigen (F8RA), Ulex europaeus agglutinin type 1 lectin (UEA-1), and CD 34, but not against keratin, epithelial membrane antigen (EMA) or S-100 protein (S100). The proliferating cell nuclear antigen (PCNA)-positive cell index was 27.5%. These pathological findings suggested a borderline malignant potential for this tumor. Thus, clinically, wide resection with or without dissection of regional lymph nodes is recommended.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalJournal of Oral Pathology and Medicine
Issue number5
Publication statusPublished - May 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


Dive into the research topics of 'Intraosseous epithelioid hemangioendothelioma of the mandible: A case report with an immunohistochemical study'. Together they form a unique fingerprint.

Cite this