Intraductal carcinoma in a surgically resected pancreas with chronic pancreatitis

Kazuhiro Mizumoto, Masahiro Tsutsumi, Shunji Kitazawa, Shigenobu Tsujita, Masaki Nakayama, Tadasu Tsujii, Hiromichi Kanehiro, Yoshiyuki Nakajima, Hiroshige Nakano, Yoichi Konishi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A 59-yr-old Japanese male presented with epigastralgia. Endoscopic retrograde cholangiopancreatography (ERCP) revealed narrowing of the inferior common bile duct and protein plugs in the main pancreatic duct. He was diagnosed as suffering from chronic pancreatitis with suspicion of a pancreatic head tumor, and a pancreatoduodenectomy was performed. Histologically, a diffuse chronic pancreatitis was evident in the resected pancreas. Although no tumors were seen in the head portion of the pancreas around the inferior common bile duct, an intraductal carcinoma was found in the second branch of Santorini's duct. Precancerous alteration of the duct epithelium, presenting papillary hyperplasia, and atypical hyperplasia were observed in areas continuous with the intraductal carcinoma. Immunohistochemically, carcinoembronic antigen (CEA) was specifically expressed in atypical hyperplasia and intraductal carcinoma, but not in papillary hyperplasia.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalInternational Journal of Pancreatology
Issue number4
Publication statusPublished - Dec 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Endocrinology
  • Gastroenterology


Dive into the research topics of 'Intraductal carcinoma in a surgically resected pancreas with chronic pancreatitis'. Together they form a unique fingerprint.

Cite this