Intracranial hemorrhage during dabigatran treatment - Case series of eight patients -

Motohiro Komori, Masahiro Yasaka, Kazuhito Kokuba, Hideki Matsuoka, Shigeru Fujimoto, Megumu Yoshida, Katsuharu Kameda, Tadahisa Shono, Shinji Nagata, Tetsuro Ago, Takanari Kitazono, Yasushi Okada

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Background: The incidence of intracranial bleeding during dabigatran treatment is lower than that during warfarin treatment. The characteristics of intracranial hemorrhage during dabigatran therapy, however, remain unclear. Methods and Results: The clinical data and treatment summaries of 9 intracranial bleeds that developed during dabigatran treatment in 8 patients with non-valvular atrial fibrillation were retrospectively reviewed. Five patients had small-moderate subdural hematomas, 2 had intracerebral hemorrhage and 1 had traumatic subarachnoid and parenchymal hemorrhage associated with cerebral contusion. Activated partial thromboplastin time upon admission ranged from 31.6 to 72.4 s. After admission, systolic blood pressure in the 2 patients with intracerebral hemorrhage was maintained below 140 mmHg, and the subdural hematomas in 4 patients were surgically treated. None of the hematomas became enlarged and outcome was good in most cases. Conclusions: Hematomas that arise due to acute intracranial bleeding during dabigatran treatment seem to remain small to moderate, hard to expand, and manageable.

Original languageEnglish
Pages (from-to)1335-1341
Number of pages7
JournalCirculation Journal
Issue number6
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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