TY - JOUR
T1 - Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks
AU - Bungo, Takashi
AU - Izumi, Tomofumi
AU - Kawamura, Kazuya
AU - Takagi, Tomo
AU - Ueda, Hiroshi
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science.
PY - 2003/12/12
Y1 - 2003/12/12
N2 - This study was designed to compare the effects of muscimol (GABA A agonist), baclofen (GABAB agonist) and nipecotic acid (GABA uptake inhibitor) on food intake in two chicken strains (meat-type and layer-type chicks). The intracerebroventricular (ICV) injection of all GABA agents induced hyperphagia in layer-type chicks. However, in broiler chicks, there were similar tendencies with muscimol and nipecotic acid but not significantly different. Conversely, ICV injection of baclofen depressed feeding of broiler chicks. These results suggest that there are some differences in central GABAergic systems between these strains of chicks, but GABAergic systems have an important role in the regulation of food intake in neonatal chicks.
AB - This study was designed to compare the effects of muscimol (GABA A agonist), baclofen (GABAB agonist) and nipecotic acid (GABA uptake inhibitor) on food intake in two chicken strains (meat-type and layer-type chicks). The intracerebroventricular (ICV) injection of all GABA agents induced hyperphagia in layer-type chicks. However, in broiler chicks, there were similar tendencies with muscimol and nipecotic acid but not significantly different. Conversely, ICV injection of baclofen depressed feeding of broiler chicks. These results suggest that there are some differences in central GABAergic systems between these strains of chicks, but GABAergic systems have an important role in the regulation of food intake in neonatal chicks.
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U2 - 10.1016/j.brainres.2003.09.017
DO - 10.1016/j.brainres.2003.09.017
M3 - Article
C2 - 14642853
AN - SCOPUS:0344851650
SN - 0006-8993
VL - 993
SP - 235
EP - 238
JO - Brain Research
JF - Brain Research
IS - 1-2
ER -