TY - JOUR
T1 - Intracerebroventricular injection of mammalian and chicken glucagon-like peptide-1 inhibits food intake of the neonatal chick
AU - Furuse, Mitsuhiro
AU - Matsumoto, Megumi
AU - Okumura, Jun Ichi
AU - Sugahara, Kunio
AU - Hasegawa, Shin
N1 - Funding Information:
This study was supported by grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan.
PY - 1997/4/25
Y1 - 1997/4/25
N2 - Glucagon-like peptide-1 (GLP-1), structurally similar to glucagon, is synthesized from a larger precursor, preproglucagon, and has been postulated to be a novel incretin. Recently, it was reported that central administration of GLP-1 decreased food intake in rats. The amino acid sequences of GLP-1 are identical in all mammals, and chicken GLP-1 exhibits a high homology with mammalian GLP-1. The aim of this study was to elucidate whether central injection of mammalian or chicken GLP-1 inhibits food intake in the chick, and to compare their effects. Intracerebroventricular administration of mammalian and chicken GLP-1 strongly inhibited food intake of chicks. However, the suppressive effect of both GLP-1 on food intake was similar. These results show that GLP-1 with a variety of amino acid sequences may be the most potent inhibitor of food intake in the chicken.
AB - Glucagon-like peptide-1 (GLP-1), structurally similar to glucagon, is synthesized from a larger precursor, preproglucagon, and has been postulated to be a novel incretin. Recently, it was reported that central administration of GLP-1 decreased food intake in rats. The amino acid sequences of GLP-1 are identical in all mammals, and chicken GLP-1 exhibits a high homology with mammalian GLP-1. The aim of this study was to elucidate whether central injection of mammalian or chicken GLP-1 inhibits food intake in the chick, and to compare their effects. Intracerebroventricular administration of mammalian and chicken GLP-1 strongly inhibited food intake of chicks. However, the suppressive effect of both GLP-1 on food intake was similar. These results show that GLP-1 with a variety of amino acid sequences may be the most potent inhibitor of food intake in the chicken.
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U2 - 10.1016/S0006-8993(97)00190-X
DO - 10.1016/S0006-8993(97)00190-X
M3 - Article
C2 - 9163555
AN - SCOPUS:0030894242
SN - 0006-8993
VL - 755
SP - 167
EP - 169
JO - Brain Research
JF - Brain Research
IS - 1
ER -