TY - JOUR
T1 - Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks
AU - Tachibana, T.
AU - Tanaka, S.
AU - Furuse, M.
AU - Hasegawa, S.
AU - Kato, H.
AU - Sugahara, K.
PY - 2002/3
Y1 - 2002/3
N2 - 1. We measured the concentrations of dopamine (DA), norepinephrine (NE), epinephrine (E) and 5-hydroxytryptamine (5-HT) in the hypothalamus of 21-d-old male brown-egg layer-type chicks after intracerebroventricular injection of glucagon-like peptide-1 (GLP-1). 2. The monoamine concentrations of the whole hypothalamus, paraventricular nucleus and lateral hypothalamic area were not significantly affected by GLP-1. 3. However, concentrations of DA, NE and E, but not 5-HT, in the ventromedial hypothalamic nucleus (VMH) were significantly decreased by GLP-1. 4. These observations suggest that the anorexigenic effect of GLP-I involves catecholaminergic systems in the VMH in the chick.
AB - 1. We measured the concentrations of dopamine (DA), norepinephrine (NE), epinephrine (E) and 5-hydroxytryptamine (5-HT) in the hypothalamus of 21-d-old male brown-egg layer-type chicks after intracerebroventricular injection of glucagon-like peptide-1 (GLP-1). 2. The monoamine concentrations of the whole hypothalamus, paraventricular nucleus and lateral hypothalamic area were not significantly affected by GLP-1. 3. However, concentrations of DA, NE and E, but not 5-HT, in the ventromedial hypothalamic nucleus (VMH) were significantly decreased by GLP-1. 4. These observations suggest that the anorexigenic effect of GLP-I involves catecholaminergic systems in the VMH in the chick.
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U2 - 10.1080/00071660120109971
DO - 10.1080/00071660120109971
M3 - Article
C2 - 12003328
AN - SCOPUS:0036512603
SN - 0007-1668
VL - 43
SP - 122
EP - 126
JO - British Poultry Science
JF - British Poultry Science
IS - 1
ER -