Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide

Md Monsur Ali; Motoi Oishi; Fumi Nagatsugi; Kenya Mori; Yukio Nagasaki; Kazunori Kataoka; Shigeki Sasaki

doi:10.1002/anie.200504441

Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide

Md Monsur Ali, Motoi Oishi, Fumi Nagatsugi, Kenya Mori, Yukio Nagasaki, Kazunori Kataoka, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

(Chemical Equation Presented) One mismatch is discriminated in a target mRNA sequence by an inducible alkylation system based on sulfide precursors to the nucleoside 2-amino-6-vinylpurine (see scheme). The reactive oligonucleotides were delivered into the cell as poly(ethylene glycol) (PEG) conjugates in polyion-complex (PIC) micelles and showed antisense activity of high selectivity and greater potency than that of the natural antisense oligonucleotide.

Original language	English
Pages (from-to)	3136-3140
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	19
DOIs	https://doi.org/10.1002/anie.200504441
Publication status	Published - May 5 2006

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200504441

Cite this

@article{f5f6c843d0334f67bdbb7abd589dec87,

title = "Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide",

abstract = "(Chemical Equation Presented) One mismatch is discriminated in a target mRNA sequence by an inducible alkylation system based on sulfide precursors to the nucleoside 2-amino-6-vinylpurine (see scheme). The reactive oligonucleotides were delivered into the cell as poly(ethylene glycol) (PEG) conjugates in polyion-complex (PIC) micelles and showed antisense activity of high selectivity and greater potency than that of the natural antisense oligonucleotide.",

author = "Ali, {Md Monsur} and Motoi Oishi and Fumi Nagatsugi and Kenya Mori and Yukio Nagasaki and Kazunori Kataoka and Shigeki Sasaki",

year = "2006",

month = may,

day = "5",

doi = "10.1002/anie.200504441",

language = "English",

volume = "45",

pages = "3136--3140",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "19",

}

TY - JOUR

T1 - Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide

AU - Ali, Md Monsur

AU - Oishi, Motoi

AU - Nagatsugi, Fumi

AU - Mori, Kenya

AU - Nagasaki, Yukio

AU - Kataoka, Kazunori

AU - Sasaki, Shigeki

PY - 2006/5/5

Y1 - 2006/5/5

N2 - (Chemical Equation Presented) One mismatch is discriminated in a target mRNA sequence by an inducible alkylation system based on sulfide precursors to the nucleoside 2-amino-6-vinylpurine (see scheme). The reactive oligonucleotides were delivered into the cell as poly(ethylene glycol) (PEG) conjugates in polyion-complex (PIC) micelles and showed antisense activity of high selectivity and greater potency than that of the natural antisense oligonucleotide.

AB - (Chemical Equation Presented) One mismatch is discriminated in a target mRNA sequence by an inducible alkylation system based on sulfide precursors to the nucleoside 2-amino-6-vinylpurine (see scheme). The reactive oligonucleotides were delivered into the cell as poly(ethylene glycol) (PEG) conjugates in polyion-complex (PIC) micelles and showed antisense activity of high selectivity and greater potency than that of the natural antisense oligonucleotide.

UR - http://www.scopus.com/inward/record.url?scp=33746255457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746255457&partnerID=8YFLogxK

U2 - 10.1002/anie.200504441

DO - 10.1002/anie.200504441

M3 - Article

C2 - 16572503

AN - SCOPUS:33746255457

SN - 1433-7851

VL - 45

SP - 3136

EP - 3140

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19

ER -

Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this