Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma

Satoshi Nakamura; Tomotsugu Takano; Kousei Nakatsuru; Kazuya Tsubouchi; Takuji Yamauchi; Mikiko Hashisako; Takeshi Iwasaki; Isamu Okamoto

doi:10.2169/internalmedicine.3601-24

Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma

Satoshi Nakamura, Tomotsugu Takano, Kousei Nakatsuru, Kazuya Tsubouchi, Takuji Yamauchi, Mikiko Hashisako, Takeshi Iwasaki, Isamu Okamoto

Research output: Contribution to journal › Article › peer-review

Abstract

Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF.

Original language	English
Pages (from-to)	3227-3231
Number of pages	5
Journal	Internal Medicine
Volume	63
Issue number	23
DOIs	https://doi.org/10.2169/internalmedicine.3601-24
Publication status	Published - 2024

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.3601-24

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title = "Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma",

abstract = "Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF.",

keywords = "case report, eosinophilia, interstitial pneumonia, interstitial pneumonia with autoimmune features, nodal T-follicular helper cell lymphoma",

author = "Satoshi Nakamura and Tomotsugu Takano and Kousei Nakatsuru and Kazuya Tsubouchi and Takuji Yamauchi and Mikiko Hashisako and Takeshi Iwasaki and Isamu Okamoto",

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T1 - Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma

AU - Nakamura, Satoshi

AU - Takano, Tomotsugu

AU - Nakatsuru, Kousei

AU - Tsubouchi, Kazuya

AU - Yamauchi, Takuji

AU - Hashisako, Mikiko

AU - Iwasaki, Takeshi

AU - Okamoto, Isamu

PY - 2024

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N2 - Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF.

AB - Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF.

KW - case report

KW - eosinophilia

KW - interstitial pneumonia

KW - interstitial pneumonia with autoimmune features

KW - nodal T-follicular helper cell lymphoma

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Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma

Abstract

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