Interrelationship of cellular fluorescein formation ability, an indication of cell viability, with environmental factors and with aryl hydrocarbon hydroxylase activity

Chikako Kiyohara; Tomio Hirohata; Masanori Kuratsune; Junya Nagayama

doi:10.1016/0045-6535(91)90050-N

Interrelationship of cellular fluorescein formation ability, an indication of cell viability, with environmental factors and with aryl hydrocarbon hydroxylase activity

Chikako Kiyohara, Tomio Hirohata, Masanori Kuratsune, Junya Nagayama

Social Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Fifty-eight lymphoblastoid cell lines were determined both for their cellular fluorescein formation ability (CFFA) and aryl hydrocarbon hydroxylase (AHH) activities, while each one was interviewed for several factors of his (her) living environment. Simple correlation coefficients of CFFA were found to be correlated positively with the daily use of oil stoves and negatively with AHH inducibility. Multivariate analysis performed to obtain partial regression coefficient indicated that CFFA was correlated negatively with the 3-methylcholanthrene (MC)-induced AHH activity. These results suggest the presence of a negative relationship between CFFA and the drug metabolizing ability, AHH activity, in the human lymphoblastoid cells.

Original language	English
Pages (from-to)	739-746
Number of pages	8
Journal	Chemosphere
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/0045-6535(91)90050-N
Publication status	Published - 1991

All Science Journal Classification (ASJC) codes

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(91)90050-N

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title = "Interrelationship of cellular fluorescein formation ability, an indication of cell viability, with environmental factors and with aryl hydrocarbon hydroxylase activity",

abstract = "Fifty-eight lymphoblastoid cell lines were determined both for their cellular fluorescein formation ability (CFFA) and aryl hydrocarbon hydroxylase (AHH) activities, while each one was interviewed for several factors of his (her) living environment. Simple correlation coefficients of CFFA were found to be correlated positively with the daily use of oil stoves and negatively with AHH inducibility. Multivariate analysis performed to obtain partial regression coefficient indicated that CFFA was correlated negatively with the 3-methylcholanthrene (MC)-induced AHH activity. These results suggest the presence of a negative relationship between CFFA and the drug metabolizing ability, AHH activity, in the human lymphoblastoid cells.",

author = "Chikako Kiyohara and Tomio Hirohata and Masanori Kuratsune and Junya Nagayama",

note = "Funding Information: This work was supported by Grant 57480203 from the Ministry of Education, Science",

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doi = "10.1016/0045-6535(91)90050-N",

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T1 - Interrelationship of cellular fluorescein formation ability, an indication of cell viability, with environmental factors and with aryl hydrocarbon hydroxylase activity

AU - Kiyohara, Chikako

AU - Hirohata, Tomio

AU - Kuratsune, Masanori

AU - Nagayama, Junya

N1 - Funding Information: This work was supported by Grant 57480203 from the Ministry of Education, Science

PY - 1991

Y1 - 1991

N2 - Fifty-eight lymphoblastoid cell lines were determined both for their cellular fluorescein formation ability (CFFA) and aryl hydrocarbon hydroxylase (AHH) activities, while each one was interviewed for several factors of his (her) living environment. Simple correlation coefficients of CFFA were found to be correlated positively with the daily use of oil stoves and negatively with AHH inducibility. Multivariate analysis performed to obtain partial regression coefficient indicated that CFFA was correlated negatively with the 3-methylcholanthrene (MC)-induced AHH activity. These results suggest the presence of a negative relationship between CFFA and the drug metabolizing ability, AHH activity, in the human lymphoblastoid cells.

AB - Fifty-eight lymphoblastoid cell lines were determined both for their cellular fluorescein formation ability (CFFA) and aryl hydrocarbon hydroxylase (AHH) activities, while each one was interviewed for several factors of his (her) living environment. Simple correlation coefficients of CFFA were found to be correlated positively with the daily use of oil stoves and negatively with AHH inducibility. Multivariate analysis performed to obtain partial regression coefficient indicated that CFFA was correlated negatively with the 3-methylcholanthrene (MC)-induced AHH activity. These results suggest the presence of a negative relationship between CFFA and the drug metabolizing ability, AHH activity, in the human lymphoblastoid cells.

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Interrelationship of cellular fluorescein formation ability, an indication of cell viability, with environmental factors and with aryl hydrocarbon hydroxylase activity

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