International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r

Ted M. Burns; Reza Sadjadi; Kimiaki Utsugisawa; Kelly G. Gwathmey; Amruta Joshi; Sarah Jones; Vera Bril; Carolina Barnett; Jeffrey T. Guptill; Donald B. Sanders; Lisa Hobson-Webb; Vern C. Juel; Janice Massey; Karissa L. Gable; Nicholas J. Silvestri; Gil Wolfe; Gary Cutter; Yuriko Nagane; Hiroyuki Murai; Masayuki Masuda; Maria Elena Farrugia; Caroline Carmichael; Simone Birnbaum; Jean Yves Hogrel; Shahriar Nafissi; Farzad Fatehi; Changyi Ou; Weibin Liu; Mark Conaway

doi:10.1002/mus.25198

International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r

Ted M. Burns, Reza Sadjadi, Kimiaki Utsugisawa, Kelly G. Gwathmey, Amruta Joshi, Sarah Jones, Vera Bril, Carolina Barnett, Jeffrey T. Guptill, Donald B. Sanders, Lisa Hobson-Webb, Vern C. Juel, Janice Massey, Karissa L. Gable, Nicholas J. Silvestri, Gil Wolfe, Gary Cutter, Yuriko Nagane, Hiroyuki Murai, Masayuki MasudaMaria Elena Farrugia, Caroline Carmichael, Simone Birnbaum, Jean Yves Hogrel, Shahriar Nafissi, Farzad Fatehi, Changyi Ou, Weibin Liu, Mark Conaway

Faculty of Medical Sciences

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Introduction: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. Methods: We first performed Rasch analysis on >1,300 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) completed surveys. Results were discussed during a conference call with specialists and biostatisticians. We decided to revise 3 items and prospectively evaluate the revised scale (MG-QOL15r) using either 3, 4, or 5 responses. Rasch analysis was then performed on >1,300 MG-QOL15r scales. Results: The MGQOL15r performed slightly better than the MG-QOL15. The 3-response option MG-QOL15r demonstrated better clinimetric properties than the 4- or 5-option scales. Relative distributions of item and person location estimates showed good coverage of disease severity. Conclusions: The MG-QOL15r is now the preferred HRQOL instrument for MG because of improved clinimetrics and ease of use. This revision does not negate previous studies or interpretations of results using the MG-QOL15. Muscle Nerve 54: 1015–1022, 2016.

Original language	English
Pages (from-to)	1015-1022
Number of pages	8
Journal	Muscle and Nerve
Volume	54
Issue number	6
DOIs	https://doi.org/10.1002/mus.25198
Publication status	Published - Dec 1 2016

All Science Journal Classification (ASJC) codes

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

Access to Document

10.1002/mus.25198

Cite this

Burns, T. M., Sadjadi, R., Utsugisawa, K., Gwathmey, K. G., Joshi, A., Jones, S., Bril, V., Barnett, C., Guptill, J. T., Sanders, D. B., Hobson-Webb, L., Juel, V. C., Massey, J., Gable, K. L., Silvestri, N. J., Wolfe, G., Cutter, G., Nagane, Y., Murai, H., ... Conaway, M. (2016). International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r. Muscle and Nerve, 54(6), 1015-1022. https://doi.org/10.1002/mus.25198

Burns, TM, Sadjadi, R, Utsugisawa, K, Gwathmey, KG, Joshi, A, Jones, S, Bril, V, Barnett, C, Guptill, JT, Sanders, DB, Hobson-Webb, L, Juel, VC, Massey, J, Gable, KL, Silvestri, NJ, Wolfe, G, Cutter, G, Nagane, Y, Murai, H, Masuda, M, Farrugia, ME, Carmichael, C, Birnbaum, S, Hogrel, JY, Nafissi, S, Fatehi, F, Ou, C, Liu, W & Conaway, M 2016, 'International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r', Muscle and Nerve, vol. 54, no. 6, pp. 1015-1022. https://doi.org/10.1002/mus.25198

@article{c5888b7da16c4eb3ac3c9dae98b5c75d,

title = "International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r",

abstract = "Introduction: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. Methods: We first performed Rasch analysis on >1,300 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) completed surveys. Results were discussed during a conference call with specialists and biostatisticians. We decided to revise 3 items and prospectively evaluate the revised scale (MG-QOL15r) using either 3, 4, or 5 responses. Rasch analysis was then performed on >1,300 MG-QOL15r scales. Results: The MGQOL15r performed slightly better than the MG-QOL15. The 3-response option MG-QOL15r demonstrated better clinimetric properties than the 4- or 5-option scales. Relative distributions of item and person location estimates showed good coverage of disease severity. Conclusions: The MG-QOL15r is now the preferred HRQOL instrument for MG because of improved clinimetrics and ease of use. This revision does not negate previous studies or interpretations of results using the MG-QOL15. Muscle Nerve 54: 1015–1022, 2016.",

author = "Burns, {Ted M.} and Reza Sadjadi and Kimiaki Utsugisawa and Gwathmey, {Kelly G.} and Amruta Joshi and Sarah Jones and Vera Bril and Carolina Barnett and Guptill, {Jeffrey T.} and Sanders, {Donald B.} and Lisa Hobson-Webb and Juel, {Vern C.} and Janice Massey and Gable, {Karissa L.} and Silvestri, {Nicholas J.} and Gil Wolfe and Gary Cutter and Yuriko Nagane and Hiroyuki Murai and Masayuki Masuda and Farrugia, {Maria Elena} and Caroline Carmichael and Simone Birnbaum and Hogrel, {Jean Yves} and Shahriar Nafissi and Farzad Fatehi and Changyi Ou and Weibin Liu and Mark Conaway",

note = "Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2016",

month = dec,

day = "1",

doi = "10.1002/mus.25198",

language = "English",

volume = "54",

pages = "1015--1022",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r

AU - Burns, Ted M.

AU - Sadjadi, Reza

AU - Utsugisawa, Kimiaki

AU - Gwathmey, Kelly G.

AU - Joshi, Amruta

AU - Jones, Sarah

AU - Bril, Vera

AU - Barnett, Carolina

AU - Guptill, Jeffrey T.

AU - Sanders, Donald B.

AU - Hobson-Webb, Lisa

AU - Juel, Vern C.

AU - Massey, Janice

AU - Gable, Karissa L.

AU - Silvestri, Nicholas J.

AU - Wolfe, Gil

AU - Cutter, Gary

AU - Nagane, Yuriko

AU - Murai, Hiroyuki

AU - Masuda, Masayuki

AU - Farrugia, Maria Elena

AU - Carmichael, Caroline

AU - Birnbaum, Simone

AU - Hogrel, Jean Yves

AU - Nafissi, Shahriar

AU - Fatehi, Farzad

AU - Ou, Changyi

AU - Liu, Weibin

AU - Conaway, Mark

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Introduction: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. Methods: We first performed Rasch analysis on >1,300 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) completed surveys. Results were discussed during a conference call with specialists and biostatisticians. We decided to revise 3 items and prospectively evaluate the revised scale (MG-QOL15r) using either 3, 4, or 5 responses. Rasch analysis was then performed on >1,300 MG-QOL15r scales. Results: The MGQOL15r performed slightly better than the MG-QOL15. The 3-response option MG-QOL15r demonstrated better clinimetric properties than the 4- or 5-option scales. Relative distributions of item and person location estimates showed good coverage of disease severity. Conclusions: The MG-QOL15r is now the preferred HRQOL instrument for MG because of improved clinimetrics and ease of use. This revision does not negate previous studies or interpretations of results using the MG-QOL15. Muscle Nerve 54: 1015–1022, 2016.

AB - Introduction: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. Methods: We first performed Rasch analysis on >1,300 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) completed surveys. Results were discussed during a conference call with specialists and biostatisticians. We decided to revise 3 items and prospectively evaluate the revised scale (MG-QOL15r) using either 3, 4, or 5 responses. Rasch analysis was then performed on >1,300 MG-QOL15r scales. Results: The MGQOL15r performed slightly better than the MG-QOL15. The 3-response option MG-QOL15r demonstrated better clinimetric properties than the 4- or 5-option scales. Relative distributions of item and person location estimates showed good coverage of disease severity. Conclusions: The MG-QOL15r is now the preferred HRQOL instrument for MG because of improved clinimetrics and ease of use. This revision does not negate previous studies or interpretations of results using the MG-QOL15. Muscle Nerve 54: 1015–1022, 2016.

UR - http://www.scopus.com/inward/record.url?scp=84995550194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995550194&partnerID=8YFLogxK

U2 - 10.1002/mus.25198

DO - 10.1002/mus.25198

M3 - Article

AN - SCOPUS:84995550194

SN - 0148-639X

VL - 54

SP - 1015

EP - 1022

JO - Muscle and Nerve

JF - Muscle and Nerve

IS - 6

ER -

International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this