Intermediate water on calcium phosphate minerals: ITS origin and role in crystal growth

Masahiro Okada, Emilio Satoshi Hara, Daisuke Kobayashi, Shoki Kai, Keiko Ogura, Masaru Tanaka, Takuya Matsumoto

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Water molecules are known to play crucial roles both in the formation and biological function of materials. Herein, we show the presence of “intermediate water” on an inorganic solid material, hydroxyapatite. In vitro experiments revealed that Mg substitution of apatite significantly enriched the amount of intermediate water, possibly due to the proton transfer to a hydrogen-bonded network of water around HPO42− on divalent-cation-deficient apatite surfaces. The intermediate water formation related to a markedl su ressed rotein adsor tion on a atite Anal sis of bone a atites suggested that the intermediate water on minerals could play crucial roles in regulating crystal growth.

Original languageEnglish
Pages (from-to)981-986
Number of pages6
JournalACS Applied Bio Materials
Issue number3
Publication statusPublished - Mar 2019

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • General Chemistry
  • Biomedical Engineering
  • Biochemistry, medical


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