Interleukin-18 in human milk

Yasushi Takahata, Hidetoshi Takada, Akihiko Nomura, Koichi Ohshima, Hideki Nakayama, Tomoteru Tsuda, Hitoo Nakano, Toshiro Hara

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


We analyzed IL-18 levels of human milk. Colostrum contained significantly higher levels of IL-18 compared with early milk and mature milk. By stepwise multiple linear regression analysis, preterm delivery and pregnancy complications of mothers significantly correlated with high levels of IL-18 in human milk (p = 0.0007 and 0.0018, respectively). There was a significant correlation between the levels of IL-18 and soluble Fas ligand in colostrum (p = 0.0003). IL-18 was detected in actively secreting epithelial cells in lactating mammary gland by immunohistochemical staining. These results suggest that IL-18 in colostrum plays an important role in host defense of high-risk neonates.

Original languageEnglish
Pages (from-to)268-272
Number of pages5
JournalPediatric Research
Issue number2
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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