TY - JOUR
T1 - Interleukin-1 receptor antagonist and interleukin-4 in gingival crevicular fluid of patients with inflammatory periodontal disease
AU - Kabashima, Hiroaki
AU - Nagata, Kengo
AU - Hashiguchi, Isamu
AU - Toriya, Yoshikazu
AU - Iijima, Tadahiko
AU - Maki, Kouji
AU - Maeda, Katsumasa
PY - 1996
Y1 - 1996
N2 - Interleukin-1 receptor antagonist (IL-1ra) and interleukin-4 (IL-4) were detected in gingival crevicular fluid (GCF) by an immunochemical method. However, we could not detect IL-4 in GCF from severe inflammation sites. In addition, we sought to detect which cells had produced cytokines in moderately inflamed gingival tissues by means of immunohistochemistry. The cell types expressing CD 68 were identified as monocytes/macrophages and stained positively for IL-1ra. The helper T cells identified by immunostaining for CD 4 stained positively for IL-4. These results suggest that IL-4 is one of the mediators regulating the degree of local inflammation in periodontal disease.
AB - Interleukin-1 receptor antagonist (IL-1ra) and interleukin-4 (IL-4) were detected in gingival crevicular fluid (GCF) by an immunochemical method. However, we could not detect IL-4 in GCF from severe inflammation sites. In addition, we sought to detect which cells had produced cytokines in moderately inflamed gingival tissues by means of immunohistochemistry. The cell types expressing CD 68 were identified as monocytes/macrophages and stained positively for IL-1ra. The helper T cells identified by immunostaining for CD 4 stained positively for IL-4. These results suggest that IL-4 is one of the mediators regulating the degree of local inflammation in periodontal disease.
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U2 - 10.1111/j.1600-0714.1996.tb00295.x
DO - 10.1111/j.1600-0714.1996.tb00295.x
M3 - Article
C2 - 8930824
AN - SCOPUS:0030250340
SN - 0904-2512
VL - 25
SP - 449
EP - 455
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
IS - 8
ER -
