Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Takanori Akagi; Yuta Matsumura; Masaya Yasui; Emiko Minami; Hidemasa Inoue; Takahiro Masuda; Hidetoshi Tozaki-Saitoh; Tomohiko Tamura; Kazue Mizumura; Makoto Tsuda; Hiroshi Kiyama; Kazuhide Inoue

doi:10.1254/jphs.14143SC

Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Takanori Akagi, Yuta Matsumura, Masaya Yasui, Emiko Minami, Hidemasa Inoue, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Kazue Mizumura, Makoto Tsuda, Hiroshi Kiyama, Kazuhide Inoue

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Abstract

We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.

Original language	English
Pages (from-to)	172-176
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	126
Issue number	2
DOIs	https://doi.org/10.1254/jphs.14143SC
Publication status	Published - 2014

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Tozaki-Saitoh, H., Tamura, T., Mizumura, K., Tsuda, M., Kiyama, H., & Inoue, K. (2014). Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents. Journal of Pharmacological Sciences, 126(2), 172-176. https://doi.org/10.1254/jphs.14143SC

Akagi, T, Matsumura, Y, Yasui, M, Minami, E, Inoue, H, Masuda, T, Tozaki-Saitoh, H, Tamura, T, Mizumura, K, Tsuda, M, Kiyama, H & Inoue, K 2014, 'Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents', Journal of Pharmacological Sciences, vol. 126, no. 2, pp. 172-176. https://doi.org/10.1254/jphs.14143SC

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title = "Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents",

abstract = "We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.",

author = "Takanori Akagi and Yuta Matsumura and Masaya Yasui and Emiko Minami and Hidemasa Inoue and Takahiro Masuda and Hidetoshi Tozaki-Saitoh and Tomohiko Tamura and Kazue Mizumura and Makoto Tsuda and Hiroshi Kiyama and Kazuhide Inoue",

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AU - Akagi, Takanori

AU - Matsumura, Yuta

AU - Yasui, Masaya

AU - Minami, Emiko

AU - Inoue, Hidemasa

AU - Masuda, Takahiro

AU - Tozaki-Saitoh, Hidetoshi

AU - Tamura, Tomohiko

AU - Mizumura, Kazue

AU - Tsuda, Makoto

AU - Kiyama, Hiroshi

AU - Inoue, Kazuhide

PY - 2014

Y1 - 2014

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AB - We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.

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Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

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