Interferon-γ-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas

Hiroaki Kabashima, Kengo Nagata, Katsumasa Maeda, Tadahiko Iijima

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30 Citations (Scopus)


Periapical granulomas contain a large number of T lymphocytes and monocytes/macrophages and a small number of B lymphocytes and polymorphonuclear leukocytes. Sections from eight periapical granulomas were stained by a variety of immunohistochemical methods. The vascular endothelial cells stained positively for intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Helper T cells were identified by immunostaining for CD4 and stained positively for interferon-γ (IFN-γ). However, CD4-positive T cells did not stain for interleukin-4 (IL-4). Monocytes/macrophages were identified by immunostaining for CD68 and stained positively for IL-1α or inducible nitric oxide synthase (INOS). IL-1β could not be detected in the same samples. No cytokine expression was observed in B cells identified by immunostaining for CD20. IFN-γ- and iNOS-positive cells could not be detected in clinically healthy periodontal ligament being used as a negative control. These results suggest that the IFN-γ-producing T cells and iNOS-positive cells may modulate the progress of disease in local inflammation sites such as in periapical granulomas.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalJournal of Oral Pathology and Medicine
Issue number3
Publication statusPublished - Mar 1998

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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