Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces

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The interfacial structures of a blood-compatible polymer, poly(2-methoxyethyl acrylate) (PMEA), and several analogues were investigated by atomic force microscopy (AFM). The blood-compatible polymers exhibited nanometer-scale protrusions that spontaneously and homogeneously formed at polymer/water and polymer/phosphate-buffered saline interfaces. AFM observation also revealed that fibrinogen adsorption occurred locally on the protrusions rather than uniformly at the interface, with the regions adjacent to the protrusions apparently preventing the adsorption of fibrinogen. The formation of these interfacial structures may be due to in-plane microphase separation of polymer and water at the interface.

Original languageEnglish
Pages (from-to)2122-2126
Number of pages5
JournalACS Biomaterials Science and Engineering
Issue number12
Publication statusPublished - Dec 12 2016

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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