Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma

Nobuko Yasutake; Yoshihiro Ohishi; Kenichi Taguchi; Yuka Hiraki; Masafumi Oya; Yumi Oshiro; Mari Mine; Takeshi Iwasaki; Hidetaka Yamamoto; Kenichi Kohashi; Kenzo Sonoda; Kiyoko Kato; Yoshinao Oda

doi:10.1111/his.13422

Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma

Nobuko Yasutake, Yoshihiro Ohishi, Kenichi Taguchi, Yuka Hiraki, Masafumi Oya, Yumi Oshiro, Mari Mine, Takeshi Iwasaki, Hidetaka Yamamoto, Kenichi Kohashi, Kenzo Sonoda, Kiyoko Kato, Yoshinao Oda

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Abstract

Aims: The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS). Methods and results: We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study. Conclusions: IMP3 expression in ULMS could be a marker of a poor prognosis.

Original language	English
Pages (from-to)	739-748
Number of pages	10
Journal	Histopathology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1111/his.13422
Publication status	Published - Apr 2018

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Histology

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10.1111/his.13422

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@article{514c2d3148114956aaa432d11946c3c3,

title = "Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma",

abstract = "Aims: The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS). Methods and results: We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study. Conclusions: IMP3 expression in ULMS could be a marker of a poor prognosis.",

author = "Nobuko Yasutake and Yoshihiro Ohishi and Kenichi Taguchi and Yuka Hiraki and Masafumi Oya and Yumi Oshiro and Mari Mine and Takeshi Iwasaki and Hidetaka Yamamoto and Kenichi Kohashi and Kenzo Sonoda and Kiyoko Kato and Yoshinao Oda",

note = "Funding Information: The authors thank Y. Nakashima, K. Nishiyama and M. Nishida (Japanese Red Cross Fukuoka Hospital, Fukuoka), J. Motoshita and Y. Ueoka (Hamanomachi Hospital, Fukuoka), Y. Yoshikawa and H. Sumioki (Beppu Medical Center, Oita), S. Kato and K. Sakai (Saiseikai Fukuoka General Hospital, Fukuoka) for providing clinical histological data. We are grateful to N. Niino and J. Godo (Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan), and the Research Support center, Kyushu University Graduate School of Medical Science, Kyushu University for technical support. The English used in this article was revised by KN International. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons Ltd",

year = "2018",

month = apr,

doi = "10.1111/his.13422",

language = "English",

volume = "72",

pages = "739--748",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma

AU - Yasutake, Nobuko

AU - Ohishi, Yoshihiro

AU - Taguchi, Kenichi

AU - Hiraki, Yuka

AU - Oya, Masafumi

AU - Oshiro, Yumi

AU - Mine, Mari

AU - Iwasaki, Takeshi

AU - Yamamoto, Hidetaka

AU - Kohashi, Kenichi

AU - Sonoda, Kenzo

AU - Kato, Kiyoko

AU - Oda, Yoshinao

N1 - Funding Information: The authors thank Y. Nakashima, K. Nishiyama and M. Nishida (Japanese Red Cross Fukuoka Hospital, Fukuoka), J. Motoshita and Y. Ueoka (Hamanomachi Hospital, Fukuoka), Y. Yoshikawa and H. Sumioki (Beppu Medical Center, Oita), S. Kato and K. Sakai (Saiseikai Fukuoka General Hospital, Fukuoka) for providing clinical histological data. We are grateful to N. Niino and J. Godo (Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan), and the Research Support center, Kyushu University Graduate School of Medical Science, Kyushu University for technical support. The English used in this article was revised by KN International. Publisher Copyright: © 2017 John Wiley & Sons Ltd

PY - 2018/4

Y1 - 2018/4

N2 - Aims: The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS). Methods and results: We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study. Conclusions: IMP3 expression in ULMS could be a marker of a poor prognosis.

AB - Aims: The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS). Methods and results: We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study. Conclusions: IMP3 expression in ULMS could be a marker of a poor prognosis.

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U2 - 10.1111/his.13422

DO - 10.1111/his.13422

M3 - Article

C2 - 29077232

AN - SCOPUS:85040046715

SN - 0309-0167

VL - 72

SP - 739

EP - 748

JO - Histopathology

JF - Histopathology

IS - 5

ER -

Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma

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