TY - JOUR
T1 - Insulin Function in Peripheral Taste Organ Homeostasis
AU - Takai, Shingo
AU - Shigemura, Noriatsu
N1 - Funding Information:
This work was supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) grants 17 K17938 (S.T.) and 19H03818 (N.S.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
PY - 2020/6
Y1 - 2020/6
N2 - Purpose of Review: Taste is the sensory system primarily devoted to the selection of what we eat. Various internal factors are likely involved in the modulation of taste sensitivity or homeostasis in the context of one’s general nutritional condition. For ameliorating or preventing lifestyle-related diseases, it is important to understand how our taste system is maintained and disrupted. This review focuses on insulin, the most potent anabolic agent in our body and a possible modulator of taste sensation, in the peripheral taste system. Recent Findings: The insulin receptor is expressed in taste buds and taste progenitor/stem cells. Insulin expression itself is also reported in taste buds. Recent studies suggest that insulin signaling might contribute to the regulation of taste cell generation. Summary: Insulin in blood circulation or in taste buds might influence taste cell turnover and certain taste sensitivities. Hyperinsulinemia is one possible cause of taste disorders frequently observed in diabetes patients.
AB - Purpose of Review: Taste is the sensory system primarily devoted to the selection of what we eat. Various internal factors are likely involved in the modulation of taste sensitivity or homeostasis in the context of one’s general nutritional condition. For ameliorating or preventing lifestyle-related diseases, it is important to understand how our taste system is maintained and disrupted. This review focuses on insulin, the most potent anabolic agent in our body and a possible modulator of taste sensation, in the peripheral taste system. Recent Findings: The insulin receptor is expressed in taste buds and taste progenitor/stem cells. Insulin expression itself is also reported in taste buds. Recent studies suggest that insulin signaling might contribute to the regulation of taste cell generation. Summary: Insulin in blood circulation or in taste buds might influence taste cell turnover and certain taste sensitivities. Hyperinsulinemia is one possible cause of taste disorders frequently observed in diabetes patients.
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U2 - 10.1007/s40496-020-00266-2
DO - 10.1007/s40496-020-00266-2
M3 - Review article
AN - SCOPUS:85100654096
SN - 2196-3002
VL - 7
SP - 168
EP - 173
JO - Current Oral Health Reports
JF - Current Oral Health Reports
IS - 2
ER -
