Inhibitory effects of pentobarbital on glutamate-induced calcium increase in presynaptic nerve terminals

Seiko Kitahara; Shinichi Ito; Yuji Motono; Yoshimi Ikemoto

doi:10.1016/j.ics.2005.07.083

Inhibitory effects of pentobarbital on glutamate-induced calcium increase in presynaptic nerve terminals

Seiko Kitahara, Shinichi Ito, Yuji Motono, Yoshimi Ikemoto

Maxillofacial Diagnostic & Surgical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We investigated the effects of pentobarbital on the intracellular Ca²⁺concentration ([Ca²⁺]_i) of the presynaptic nerve terminals (boutons). In the presence of external Ca²⁺, glutamate increased [Ca²⁺]_i both in the neurons and in the presynaptic terminals. Pentobarbital suppressed the increase in neurons and in boutons with greater effects on the boutons. Our results indicated that pentobarbital may modulate the neurotransmission by inhibiting the transmitter release, which is induced by glutamate.

Original language	English
Pages (from-to)	269-270
Number of pages	2
Journal	International Congress Series
Volume	1283
DOIs	https://doi.org/10.1016/j.ics.2005.07.083
Publication status	Published - Nov 2005

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/j.ics.2005.07.083

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title = "Inhibitory effects of pentobarbital on glutamate-induced calcium increase in presynaptic nerve terminals",

abstract = "We investigated the effects of pentobarbital on the intracellular Ca2+concentration ([Ca2+]i) of the presynaptic nerve terminals (boutons). In the presence of external Ca2+, glutamate increased [Ca2+]i both in the neurons and in the presynaptic terminals. Pentobarbital suppressed the increase in neurons and in boutons with greater effects on the boutons. Our results indicated that pentobarbital may modulate the neurotransmission by inhibiting the transmitter release, which is induced by glutamate.",

author = "Seiko Kitahara and Shinichi Ito and Yuji Motono and Yoshimi Ikemoto",

year = "2005",

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doi = "10.1016/j.ics.2005.07.083",

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journal = "International Congress Series",

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T1 - Inhibitory effects of pentobarbital on glutamate-induced calcium increase in presynaptic nerve terminals

AU - Kitahara, Seiko

AU - Ito, Shinichi

AU - Motono, Yuji

AU - Ikemoto, Yoshimi

PY - 2005/11

Y1 - 2005/11

N2 - We investigated the effects of pentobarbital on the intracellular Ca2+concentration ([Ca2+]i) of the presynaptic nerve terminals (boutons). In the presence of external Ca2+, glutamate increased [Ca2+]i both in the neurons and in the presynaptic terminals. Pentobarbital suppressed the increase in neurons and in boutons with greater effects on the boutons. Our results indicated that pentobarbital may modulate the neurotransmission by inhibiting the transmitter release, which is induced by glutamate.

AB - We investigated the effects of pentobarbital on the intracellular Ca2+concentration ([Ca2+]i) of the presynaptic nerve terminals (boutons). In the presence of external Ca2+, glutamate increased [Ca2+]i both in the neurons and in the presynaptic terminals. Pentobarbital suppressed the increase in neurons and in boutons with greater effects on the boutons. Our results indicated that pentobarbital may modulate the neurotransmission by inhibiting the transmitter release, which is induced by glutamate.

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SP - 269

EP - 270

JO - International Congress Series

JF - International Congress Series

ER -

Inhibitory effects of pentobarbital on glutamate-induced calcium increase in presynaptic nerve terminals

Abstract

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