Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.

Original languageEnglish
Pages (from-to)1966-1969
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science


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