Inhibitors targeting two-component signal transduction

Takafumi Watanabe, Ario Okada, Yasuhiro Gotoh, Ryutaro Utsumi

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Citations (Scopus)


A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.

Original languageEnglish
Title of host publicationBacterial Signal Transduction
Subtitle of host publicationNetworks and Drug Targets
EditorsRyutaro Utsumi
Number of pages8
Publication statusPublished - Dec 1 2008
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Inhibitors targeting two-component signal transduction'. Together they form a unique fingerprint.

Cite this