Inhibitors targeting two-component signal transduction

Takafumi Watanabe; Ario Okada; Yasuhiro Gotoh; Ryutaro Utsumi

doi:10.1007/978-0-387-78885-2_16

Inhibitors targeting two-component signal transduction

Takafumi Watanabe, Ario Okada, Yasuhiro Gotoh, Ryutaro Utsumi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

33 Citations (Scopus)

Abstract

A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.

Original language	English
Title of host publication	Bacterial Signal Transduction
Subtitle of host publication	Networks and Drug Targets
Editors	Ryutaro Utsumi
Pages	229-236
Number of pages	8
DOIs	https://doi.org/10.1007/978-0-387-78885-2_16
Publication status	Published - Dec 1 2008
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	631
ISSN (Print)	0065-2598

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-0-387-78885-2_16

Cite this

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Inhibitors targeting two-component signal transduction

Abstract

Publication series

All Science Journal Classification (ASJC) codes

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