Inhibitionof cell motility by fucoidan derived from Cladosiphon okamuranus

Yumi Yamasaki, Yoshiko Ando, Masao Yamasaki, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticlepeer-review


Fucoidanis anactive component of seaweed that has beenshownto exhibit a number of biological regulation effects, such as inhibition of proliferation and induction of apoptosis, invarious tumor cells. Inthis study, we demonstrated that fucoidanisolated from Cladosiphon okamuranus significantly inhibited cell motility in several cancer cells in a dose-dependent manner. Fucoidan induced the disruption of stress fibers at concentrations greater than 10 μg/mL. However, fucoidanwas not shownto decrease the phosphorylationof the myosinII regulatory light chain(MRLC) at Thr18/Ser19 inB16 cells. These data suggested that the inhibition of cell motility by treatment with fucoidan was induced via a pathway other than MRLC.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Issue number7
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Food Science


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