Inhibitionof cell motility by fucoidan derived from Cladosiphon okamuranus

Yumi Yamasaki; Yoshiko Ando; Masao Yamasaki; Hirofumi Tachibana; Koji Yamada

doi:10.3136/nskkk.60.357

Inhibitionof cell motility by fucoidan derived from Cladosiphon okamuranus

Yumi Yamasaki, Yoshiko Ando, Masao Yamasaki, Hirofumi Tachibana, Koji Yamada

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Fucoidanis anactive component of seaweed that has beenshownto exhibit a number of biological regulation effects, such as inhibition of proliferation and induction of apoptosis, invarious tumor cells. Inthis study, we demonstrated that fucoidanisolated from Cladosiphon okamuranus significantly inhibited cell motility in several cancer cells in a dose-dependent manner. Fucoidan induced the disruption of stress fibers at concentrations greater than 10 μg/mL. However, fucoidanwas not shownto decrease the phosphorylationof the myosinII regulatory light chain(MRLC) at Thr18/Ser19 inB16 cells. These data suggested that the inhibition of cell motility by treatment with fucoidan was induced via a pathway other than MRLC.

Original language	English
Pages (from-to)	357-361
Number of pages	5
Journal	Nippon Shokuhin Kagaku Kogaku Kaishi
Volume	60
Issue number	7
DOIs	https://doi.org/10.3136/nskkk.60.357
Publication status	Published - 2013

All Science Journal Classification (ASJC) codes

Food Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Fucoidanis anactive component of seaweed that has beenshownto exhibit a number of biological regulation effects, such as inhibition of proliferation and induction of apoptosis, invarious tumor cells. Inthis study, we demonstrated that fucoidanisolated from Cladosiphon okamuranus significantly inhibited cell motility in several cancer cells in a dose-dependent manner. Fucoidan induced the disruption of stress fibers at concentrations greater than 10 μg/mL. However, fucoidanwas not shownto decrease the phosphorylationof the myosinII regulatory light chain(MRLC) at Thr18/Ser19 inB16 cells. These data suggested that the inhibition of cell motility by treatment with fucoidan was induced via a pathway other than MRLC.",

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year = "2013",

doi = "10.3136/nskkk.60.357",

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T1 - Inhibitionof cell motility by fucoidan derived from Cladosiphon okamuranus

AU - Yamasaki, Yumi

AU - Ando, Yoshiko

AU - Yamasaki, Masao

AU - Tachibana, Hirofumi

AU - Yamada, Koji

PY - 2013

Y1 - 2013

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AB - Fucoidanis anactive component of seaweed that has beenshownto exhibit a number of biological regulation effects, such as inhibition of proliferation and induction of apoptosis, invarious tumor cells. Inthis study, we demonstrated that fucoidanisolated from Cladosiphon okamuranus significantly inhibited cell motility in several cancer cells in a dose-dependent manner. Fucoidan induced the disruption of stress fibers at concentrations greater than 10 μg/mL. However, fucoidanwas not shownto decrease the phosphorylationof the myosinII regulatory light chain(MRLC) at Thr18/Ser19 inB16 cells. These data suggested that the inhibition of cell motility by treatment with fucoidan was induced via a pathway other than MRLC.

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Inhibitionof cell motility by fucoidan derived from Cladosiphon okamuranus

Abstract

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