TY - JOUR
T1 - Inhibition of emotional needs and emotional wellbeing predict disease progression of chronic hepatitis C patients
T2 - An 8-year prospective study
AU - Sawamoto, Ryoko
AU - Nagano, Jun
AU - Kajiwara, Eiji
AU - Sonoda, Junko
AU - Hiramoto, Tetsuya
AU - Sudo, Nobuyuki
N1 - Funding Information:
This work was partially supported by Grants-in-Aid for General Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology in Japan (N. Sudo: No. 24659350, No. 25293167, No. 25293054 and No. 26670366).
Publisher Copyright:
© 2016 The Author(s).
PY - 2016/7/29
Y1 - 2016/7/29
N2 - Background: The role of psycosocial factors in the disease progression of chronic hepatitis C (CHC) patients remains unclear. The aim of the present study was to prospectively evaluate the prognostic value of behavioral patterns and the quality of life (QOL) of patients with CHC. Methods: Two hundred and forty Japanese CHC patients (mean age 62.4 years) were assessed for behavioral patterns (Stress Inventory), QOL (Functional Assessment of Chronic Illness Therapy-Spiritual), and known prognostic factors at baseline then followed for a maximum of 8 years for disease progression, defined as either the first diagnosis of hepatocellular carcinoma (HCC) or hepatitis-related death. Results: Forty-nine events occurred during the study period (46 newly diagnosed HCC cases, three hepatitis-related deaths). In a Cox proportional hazard model including known prognostic factors and treatment-related factors as time-dependent variables, behavioral patterns associated with inhibition of emotional needs (hazard ratio (HR): 1.35; 95 % confidence interval (CI): 1.02-1.77; p = 0.036) and QOL, representing emotional wellbeing (HR 0.60; 95 % CI 0.37-0.98; p = 0.041), were each associated with the risk of disease progression. Conclusion: Psychosocial factors such as behavioral patterns relevant to the inhibition of emotional needs and emotional wellbeing independently affect the clinical course of patients with CHC.
AB - Background: The role of psycosocial factors in the disease progression of chronic hepatitis C (CHC) patients remains unclear. The aim of the present study was to prospectively evaluate the prognostic value of behavioral patterns and the quality of life (QOL) of patients with CHC. Methods: Two hundred and forty Japanese CHC patients (mean age 62.4 years) were assessed for behavioral patterns (Stress Inventory), QOL (Functional Assessment of Chronic Illness Therapy-Spiritual), and known prognostic factors at baseline then followed for a maximum of 8 years for disease progression, defined as either the first diagnosis of hepatocellular carcinoma (HCC) or hepatitis-related death. Results: Forty-nine events occurred during the study period (46 newly diagnosed HCC cases, three hepatitis-related deaths). In a Cox proportional hazard model including known prognostic factors and treatment-related factors as time-dependent variables, behavioral patterns associated with inhibition of emotional needs (hazard ratio (HR): 1.35; 95 % confidence interval (CI): 1.02-1.77; p = 0.036) and QOL, representing emotional wellbeing (HR 0.60; 95 % CI 0.37-0.98; p = 0.041), were each associated with the risk of disease progression. Conclusion: Psychosocial factors such as behavioral patterns relevant to the inhibition of emotional needs and emotional wellbeing independently affect the clinical course of patients with CHC.
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U2 - 10.1186/s13030-016-0075-3
DO - 10.1186/s13030-016-0075-3
M3 - Article
AN - SCOPUS:84979701220
SN - 1751-0759
VL - 10
JO - BioPsychoSocial Medicine
JF - BioPsychoSocial Medicine
IS - 1
M1 - 24
ER -
