Polyrotaxanes carrying 6-sulfo-GlcNAc (PRX-6S-GlcNAc) were synthesized, and the inhibitory effect on amyloid β (Aβ) aggregation was investigated. Polyrotaxane with 10% sugar content showed a stronger inhibitory effect on Aβ aggregation than monomeric 6S-GlcNAc. The inhibitory effect on Aβ aggregation depends on the sugar content of the polyrotaxane and the amount of added polyrotaxane. Polyrotaxanes with lower 6S-GlcNAc content showed a better inhibitory effect, and the addition of larger amounts of PRX-6S-GlcNAc inhibited amyloid formation. Saccharide-modified polyrotaxane showed a smaller inihibitory effect than the glycopolymer carrying 6-sulfo-GlcNAc. The inhibitory effect of polyrotaxane on Aβ aggregation was investigated by atomic force microscopy (AFM).
All Science Journal Classification (ASJC) codes
- Chemical Engineering (miscellaneous)
- Materials Science (miscellaneous)
- General Environmental Science
- Polymers and Plastics