TY - JOUR
T1 - Influences of point-spread function and time-of-flight reconstructions on standardized uptake value of lymph node metastases in FDG-PET
AU - Akamatsu, Go
AU - Mitsumoto, Katsuhiko
AU - Taniguchi, Takafumi
AU - Tsutsui, Yuji
AU - Baba, Shingo
AU - Sasaki, Masayuki
N1 - Funding Information:
The authors thank the staff of the Department of Clinical Radiology and Medical Technology at Kyushu University Hospital for their valuable clinical support. This study was supported in part by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 22611012 .
PY - 2014/1
Y1 - 2014/1
N2 - Purpose The purpose of this study was to investigate the effects of point-spread function (PSF) and time-of-flight (TOF) on the standardized uptake value (SUV) of lymph node metastasis in FDG-PET/CT. Materials and methods This study evaluated 41 lymph node metastases in 15 patients who had undergone 18F-FDG PET/CT. The lesion diameters were 2.5 cm or less. The mean short-axis diameter of the lymph nodes was 10.5 ± 3.7 mm (range 4.6-22.8 mm). The PET data were reconstructed with baseline OSEM algorithm, with OSEM + PSF, with OSEM + TOF and with OSEM + PSF + TOF. A semi-quantitative analysis was performed using the maximum and mean SUV of lymph node metastases (SUV max and SUVmean) and mean SUV of normal lung tissue (SUVlung). We also evaluated image quality using the signal-to-noise ratio in the liver (SNRliver). Results Both PSF and TOF increased the SUV of lymph node metastases. The combination of PSF and TOF increased the SUVmax by 43.3% and the SUVmean by 31.6% compared with conventional OSEM. By contrast, the SUVlung was not influenced by PSF and TOF. TOF significantly improved the SNRliver. Conclusion PSF and TOF both increased the SUV of lymph node metastases. Although PSF and TOF are considered to improve small-lesion detectability, it is important to be aware that PSF and TOF influence the accuracy of quantitative measurements.
AB - Purpose The purpose of this study was to investigate the effects of point-spread function (PSF) and time-of-flight (TOF) on the standardized uptake value (SUV) of lymph node metastasis in FDG-PET/CT. Materials and methods This study evaluated 41 lymph node metastases in 15 patients who had undergone 18F-FDG PET/CT. The lesion diameters were 2.5 cm or less. The mean short-axis diameter of the lymph nodes was 10.5 ± 3.7 mm (range 4.6-22.8 mm). The PET data were reconstructed with baseline OSEM algorithm, with OSEM + PSF, with OSEM + TOF and with OSEM + PSF + TOF. A semi-quantitative analysis was performed using the maximum and mean SUV of lymph node metastases (SUV max and SUVmean) and mean SUV of normal lung tissue (SUVlung). We also evaluated image quality using the signal-to-noise ratio in the liver (SNRliver). Results Both PSF and TOF increased the SUV of lymph node metastases. The combination of PSF and TOF increased the SUVmax by 43.3% and the SUVmean by 31.6% compared with conventional OSEM. By contrast, the SUVlung was not influenced by PSF and TOF. TOF significantly improved the SNRliver. Conclusion PSF and TOF both increased the SUV of lymph node metastases. Although PSF and TOF are considered to improve small-lesion detectability, it is important to be aware that PSF and TOF influence the accuracy of quantitative measurements.
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U2 - 10.1016/j.ejrad.2013.09.030
DO - 10.1016/j.ejrad.2013.09.030
M3 - Article
C2 - 24144448
AN - SCOPUS:84892365544
SN - 0720-048X
VL - 83
SP - 226
EP - 230
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 1
ER -