TY - JOUR
T1 - Influence of medical history in parents or siblings on the development of systemic lupus erythematosus among Japanese females
AU - Kyushu Sapporo SLE (KYSS) Study Group
AU - Tada, Yoshifumi
AU - Washio, Masakazu
AU - Horiuchi, Takahiko
AU - Kiyohara, Chikako
AU - Takahashi, Hiroki
AU - Kobashi, Gen
AU - Ide, Yuichiro
AU - Atsumi, Tatsuya
AU - Asami, Toyoko
AU - Ide, Saburo
AU - Kodama, Hiroko
AU - Akashi, Koichi
AU - Harada, Mine
AU - Tsukamoto, Hiroshi
AU - Hotokebuchi, Takao
AU - Nagasawa, Kohei
AU - Ushiyama, Osamu
AU - Mori, Mitsuru
AU - Oura, Asae
AU - Sinomura, Yasuhisa
AU - Suzuki, Hiromu
AU - Yamamoto, Motohisa
AU - Abe, Takashi
AU - Tanaka, Hisato
AU - Horita, Tetsuya
AU - Yasuda, Shinsuke
AU - Nogami, Norihiko
AU - Okamoto, Kazushi
AU - Sakamoto, Naomasa
AU - Sasaki, Satoshi
AU - Miyake, Yoshihiro
AU - Yokoyama, Tetsuji
AU - Oumi, Masayo
AU - Hirota, Yoshio
AU - Inaba, Yutaka
AU - Nagai, Masaki
N1 - Funding Information:
This work was supported in part by Health and Labour Sciences Research Grants, Research on Intractable Diseases, and the Research Committee on Epidemiology of Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan (Chief: Yutaka Inaba, 2002-04 and Masaki Nagai, 2004-10). The authors thank Takasu Town, Hokkaido Prefecture, and its town people for their kind cooperation.
Publisher Copyright:
© 2016 Japan Health Sciences University & Japan International Cultural Exchange Foundation.
PY - 2016
Y1 - 2016
N2 - Objective: To examine the influence of medical history in parents or siblings on the development of systemic lupus erythematosus (SLE) among Japanese females. Methods: 160 female SLE patients and 660 female volunteers were studied in a case-control study. Unconditional logistic regression was used to compute OR and 95% CI, with adjustment for smoking, drinking, age and region. Results: The present study demonstrated that the risk of SLE was positively associated with family histories (i.e., medical histories in parents or siblings) of SLE (OR = 5.38, 95%CI = 1.43-20.20), rheumatoid arthritis (OR = 2.54, 95%CI = 1.08-5.96), collagen diseases (OR = 3.48, 95%CI = 1.87-6.48) and autoimmune diseases (OR = 5.25, 95%CI = 1.64-16.83). Conclusion: The result of the present study implies that common genetic and potential environmental factors among family members may lead to SLE, rheumatoid arthritis, and autoimmune diseases.
AB - Objective: To examine the influence of medical history in parents or siblings on the development of systemic lupus erythematosus (SLE) among Japanese females. Methods: 160 female SLE patients and 660 female volunteers were studied in a case-control study. Unconditional logistic regression was used to compute OR and 95% CI, with adjustment for smoking, drinking, age and region. Results: The present study demonstrated that the risk of SLE was positively associated with family histories (i.e., medical histories in parents or siblings) of SLE (OR = 5.38, 95%CI = 1.43-20.20), rheumatoid arthritis (OR = 2.54, 95%CI = 1.08-5.96), collagen diseases (OR = 3.48, 95%CI = 1.87-6.48) and autoimmune diseases (OR = 5.25, 95%CI = 1.64-16.83). Conclusion: The result of the present study implies that common genetic and potential environmental factors among family members may lead to SLE, rheumatoid arthritis, and autoimmune diseases.
UR - http://www.scopus.com/inward/record.url?scp=85025665832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85025665832&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85025665832
SN - 1341-2051
VL - 23
SP - 466
EP - 469
JO - International Medical Journal
JF - International Medical Journal
IS - 5
ER -